Transmission at rod and cone ribbon synapses in the retina

WB Thoreson - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
Light-evoked voltage responses of rod and cone photoreceptor cells in the vertebrate retina
must be converted to a train of synaptic vesicle release events for transmission to …

Ribbon synapses and visual processing in the retina

L Lagnado, F Schmitz - Annual review of vision science, 2015 - annualreviews.org
The first synapses transmitting visual information contain an unusual organelle, the ribbon,
which is involved in the transport and priming of vesicles to be released at the active zone …

Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors

MJ Van Hook, CM Parmelee, M Chen… - Journal of General …, 2014 - rupress.org
At the first synapse in the vertebrate visual pathway, light-evoked changes in photoreceptor
membrane potential alter the rate of glutamate release onto second-order retinal neurons …

Mechanisms, pools, and sites of spontaneous vesicle release at synapses of rod and cone photoreceptors

KM Cork, MJ Van Hook… - European Journal of …, 2016 - Wiley Online Library
Photoreceptors have depolarized resting potentials that stimulate calcium‐dependent
release continuously from a large vesicle pool but neurons can also release vesicles without …

[HTML][HTML] The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion

CP Grabner, T Moser - Elife, 2021 - elifesciences.org
Rod photoreceptors (PRs) use ribbon synapses to transmit visual information. To signal 'no
light detected'they release glutamate continually to activate post-synaptic receptors. When …

Resting and stimulated mouse rod photoreceptors show distinct patterns of vesicle release at ribbon synapses

CL Hays, AL Sladek, WB Thoreson - Journal of General Physiology, 2020 - rupress.org
The vertebrate visual system can detect and transmit signals from single photons. To
understand how single-photon responses are transmitted, we characterized voltage …

Synaptic transmission at retinal ribbon synapses

R Heidelberger, WB Thoreson, P Witkovsky - Progress in retinal and eye …, 2005 - Elsevier
The molecular organization of ribbon synapses in photoreceptors and ON bipolar cells is
reviewed in relation to the process of neurotransmitter release. The interactions between …

Weak endogenous Ca2+ buffering supports sustained synaptic transmission by distinct mechanisms in rod and cone photoreceptors in salamander retina

MJ Van Hook, WB Thoreson - Physiological reports, 2015 - Wiley Online Library
Differences in synaptic transmission between rod and cone photoreceptors contribute to
different response kinetics in rod‐versus cone‐dominated visual pathways. We examined …

[HTML][HTML] Two pools of vesicles associated with synaptic ribbons are molecularly prepared for release

P Datta, J Gilliam, WB Thoreson, R Janz… - Biophysical journal, 2017 - cell.com
Neurons that form ribbon-style synapses are specialized for continuous exocytosis. To this
end, their synaptic terminals contain numerous synaptic vesicles, some of which are ribbon …

Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles

M Chen, MJ Van Hook, D Zenisek… - Journal of …, 2013 - Soc Neuroscience
Vesicle release from rod photoreceptors is regulated by Ca2+ entry through L-type channels
located near synaptic ribbons. We characterized sites and kinetics of vesicle release in …