Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …

Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …

Herein, we present an overview of the historic development of drugs for the treatment of
Parkinson's disease as well as prospective novel treatment forms based on targeting the …

In the CNS, an antagonistic interaction has been shown between adenosine A2A and
dopamine D2 receptors (A2 AR s and D2Rs) that may be relevant both in normal and …

The molecular interaction between adenosine A2A and dopamine D2 receptors (A2ARs and
D2Rs, respectively) within an oligomeric complex has been postulated to play a pivotal role …

The structural and functional interaction between D2 dopamine receptor (DR) and A2A
adenosine receptor (AR) has suggested these two receptors as a pharmacological target in …

There is evidence for strong functional antagonistic interactions between adenosine A 2A
receptors (A 2A Rs) and dopamine D 2 receptors (D 2 Rs). Although a close physical …

Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key
modulators of striatal neuronal function. It has been suggested that the psychostimulant …

The discovery of receptor-receptor interactions in the early 1980s, together with a more
accurate focusing of allosteric mechanisms in proteins, expanded the knowledge on the G …

Adenosine A2A and dopamine D2 receptors (A2A and D2) associate in homo-and
heteromeric complexes in the striatum, providing a structural basis for their mutual …