Progesterone and its synthetic analogues, progestins, participate in the regulation of cell
differentiation, proliferation and cell cycle progression. Progestins are usually applied for …

A new approach for the treatment of breast cancer could be the use of progesterone
antagonists. These compounds were originally developed for the inhibition of progesterone …

Progestins exert their progestational activity by binding to the progesterone receptor (form A,
the most active and form B, the less active) and may also interact with other steroid receptors …

The role of progesterone in women's cancers as well as the knowledge of the progesterone
receptor (PR) structure has prompted the design of different therapies. The aim of this review …

The pharmacology of progestins includes actions initiated by various cellular targets,
including classic receptors characterized as nuclear transcription factors (nPR), G-protein …

Progestin is a term used to describe a synthetic progestogen. The activity and potency of
synthetic progestins are mostly evaluated via parameters associated with their endometrial …

Objectives Evidence is accumulating that progestogens may play a crucial role in the
development of breast cancer under contraception and hormone therapy in reproductive …

Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In
current reproductive medicine, progesterone and its analogues play crucial roles. While the …

Keyphrases Progesterone-production, metabolism, mechanism of action, effects, clinical
use, toxicity, review 0 Hormonesprogesterone, production, metabolism, mechanism of …

Progesterone antagonists (PAs)(antiprogestins) or progesterone receptor modulators
(PRMs) form an interesting category of new hormonal agents in the treatment of breast …