Mucociliary clearance is an essential lung function that facilitates the removal of inhaled
pathogens and foreign matter unidirectionally from the airway tract and is innately achieved …

Primary ciliary dyskinesia (PCD) is a rare and heterogeneous genetic disorder that affects
the structure and function of motile cilia. In the airway epithelium, impaired ciliary motion …

Abstract Background and Objective Primary ciliary dyskinesia (PCD) is a rare genetic
disorder causing a defective ciliary structure, which predominantly leads to an impaired …

Motile airway cilia that propel contaminants out of the lung are oriented in a common
direction by planar cell polarity (PCP) signaling, which localizes PCP protein complexes to …

The functions of cilia—antenna-like organelles associated with a spectrum of disease states—
are poorly understood, particularly in human cells. Here we show that human pluripotent …

A finely regulated system of airway epithelial development governs the differentiation of
motile ciliated cells of the human respiratory tract, conferring the body's mucociliary …

The concerted movement of cilia propels inhaled contaminants out of the lungs,
safeguarding the respiratory system from toxins, pathogens, pollutants, and allergens. Motile …

Airway clearance of pathogens and particulates relies on motile cilia. Impaired cilia motility
can lead to reduction in lung function, lung transplant, or death in some cases. More than 50 …

Patient‐derived human organoids can be used to model a variety of diseases. Recently, we
described conditions for long‐term expansion of human airway organoids (AOs) directly …

The respiratory tract is protected by mucus, a complex fluid transported along the epithelial
surface by the coordinated beating of millions of microscopic cilia, hence the name of …