Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy
R Itzykson, E Fournier, C Berthon… - Blood, The Journal …, 2021 - ashpublications.org
To design a simple and reproducible classifier predicting the overall survival (OS) of patients
with acute myeloid leukemia (AML)≥ 60 years of age treated with 7+ 3, we sequenced 37 …
with acute myeloid leukemia (AML)≥ 60 years of age treated with 7+ 3, we sequenced 37 …
Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML …
S Fröhling, RF Schlenk, S Kayser, M Morhardt… - Blood, 2006 - ashpublications.org
To assess the prognostic impact of cytogenetics in elderly patients with acute myeloid
leukemia (AML) receiving intensive induction and consolidation treatment according to a …
leukemia (AML) receiving intensive induction and consolidation treatment according to a …
Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid …
We investigated the relative prognostic significance of cytogenetics in 635 adult acute
myeloid leukemia (AML) patients 60 years of age or older treated on front-line protocols …
myeloid leukemia (AML) patients 60 years of age or older treated on front-line protocols …
The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United …
D Grimwade, H Walker, G Harrison… - Blood, The Journal …, 2001 - ashpublications.org
Acute myeloid leukemia (AML) in older adults carries a poor prognosis, and the optimum
treatment remains to be determined. In younger patients, treatment stratification is frequently …
treatment remains to be determined. In younger patients, treatment stratification is frequently …
ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1
with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression …
with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression …
Most 70-to 79-year-old patients with acute myeloid leukemia do benefit from intensive treatment
G Juliusson, Swedish AML Group - Blood, The Journal of the …, 2011 - ashpublications.org
Kantarjian and coworkers have recently stated that intensive chemotherapy does not benefit
most older patients with acute myeloid leukemia (AML), 1 in contrast to the Swedish …
most older patients with acute myeloid leukemia (AML), 1 in contrast to the Swedish …
Various distinctive cytogenetic abnormalities in patients with acute myeloid leukaemia aged 60 years and older express adverse prognostic value: results from a …
B Van Der Holt, DA Breems… - British journal of …, 2007 - Wiley Online Library
Diagnostic cytogenetic abnormalities are considered important prognostic factors in patients
with acute myeloid leukaemia (AML). However, the prognostic assessments have mainly …
with acute myeloid leukaemia (AML). However, the prognostic assessments have mainly …
Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience
BC Medeiros, M Othus, M Fang… - Blood, The Journal …, 2010 - ashpublications.org
Monosomal karyotype (MK), defined as 2 or more monosomies, or a single monosomy in the
presence of structural abnormalities, has recently been reported as identifying a distinct …
presence of structural abnormalities, has recently been reported as identifying a distinct …
[HTML][HTML] Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older
VV Prassek, M Rothenberg-Thurley, MC Sauerland… - …, 2018 - ncbi.nlm.nih.gov
A cute myeloid leukemia is a disease of the elderly (median age at diagnosis, 65–70 years).
The prognosis of older acute myeloid leukemia patients is generally poor. While genetic …
The prognosis of older acute myeloid leukemia patients is generally poor. While genetic …
Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience
V Lazarevic, AS Hörstedt, B Johansson… - Blood cancer …, 2014 - nature.com
The Swedish population-based acute myeloid leukemia registry contains data from 3251
patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006 …
patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006 …