Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers
M Bucher, KRC Montaniel, L Myatt… - … origins of health and …, 2021 - cambridge.org
Obesity is a chronic condition associated with dyslipidemia and insulin resistance. Here, we
show that the offspring of obese mothers are dyslipidemic and insulin resistant from the …
show that the offspring of obese mothers are dyslipidemic and insulin resistant from the …
[HTML][HTML] Maternal obesity modulates intracellular lipid turnover in the human term placenta
B Hirschmugl, G Desoye, P Catalano… - International journal of …, 2017 - nature.com
Background: Obesity before pregnancy is associated with impaired metabolic status of the
mother and the offspring later in life. These adverse effects have been attributed to …
mother and the offspring later in life. These adverse effects have been attributed to …
[HTML][HTML] Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
AK Anam, KM Cooke, MB Dratver, JV O'Bryan… - Molecular …, 2022 - Elsevier
Objective Maternal obesity increases the incidence of excess adiposity in newborns,
resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to …
resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to …
Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta
L Song, N Wang, Y Peng, B Sun, W Cui - Nutrition, Metabolism and …, 2022 - Elsevier
Background and aims Placental lipid transport is altered in women with high prepregnancy
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …
[HTML][HTML] Obesity downregulates lipid metabolism genes in first trimester placenta
A Rasool, T Mahmoud, B Mathyk, T Kaneko-Tarui… - Scientific Reports, 2022 - nature.com
Placentas of obese women have low mitochondrial β-oxidation of fatty acids (FA) and
accumulate lipids in late pregnancy. This creates a lipotoxic environment, impairing …
accumulate lipids in late pregnancy. This creates a lipotoxic environment, impairing …
[HTML][HTML] Effect of maternal obesity with and without gestational diabetes on offspring subcutaneous and preperitoneal adipose tissue development from birth up to year …
K Uebel, K Pusch, K Gedrich, KTM Schneider… - BMC pregnancy and …, 2014 - Springer
Background Maternal obesity and gestational diabetes mellitus (GDM) may independently
influence offspring fat mass and metabolic disease susceptibility. In this pilot study, body …
influence offspring fat mass and metabolic disease susceptibility. In this pilot study, body …
Foetoplacental epigenetic changes associated with maternal metabolic dysfunction
Metabolic-related diseases are attributed to a sedentary lifestyle and eating habits, and
there is now an increased awareness regarding pregnancy as a preponderant window in …
there is now an increased awareness regarding pregnancy as a preponderant window in …
Effect of maternal obesity on placental lipid metabolism
V Calabuig-Navarro, M Haghiac, J Minium… - …, 2017 - academic.oup.com
Obese women, on average, give birth to babies with high fat mass. Placental lipid
metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is …
metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is …
[HTML][HTML] Obesity affects maternal and neonatal HDL metabolism and function
JT Stadler, MNM van Poppel, C Wadsack, M Holzer… - Antioxidants, 2023 - mdpi.com
Pregravid obesity is one of the major risk factors for pregnancy complications such as
gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in …
gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in …
IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetes
OBJECTIVE—Offspring of mothers with type 1 diabetes (OT1DM) demonstrate increased fat
deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of …
deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of …