Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers

M Bucher, KRC Montaniel, L Myatt… - … origins of health and …, 2021 - cambridge.org
Obesity is a chronic condition associated with dyslipidemia and insulin resistance. Here, we
show that the offspring of obese mothers are dyslipidemic and insulin resistant from the …

[HTML][HTML] Maternal obesity modulates intracellular lipid turnover in the human term placenta

B Hirschmugl, G Desoye, P Catalano… - International journal of …, 2017 - nature.com
Background: Obesity before pregnancy is associated with impaired metabolic status of the
mother and the offspring later in life. These adverse effects have been attributed to …

[HTML][HTML] Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity

AK Anam, KM Cooke, MB Dratver, JV O'Bryan… - Molecular …, 2022 - Elsevier
Objective Maternal obesity increases the incidence of excess adiposity in newborns,
resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to …

Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta

L Song, N Wang, Y Peng, B Sun, W Cui - Nutrition, Metabolism and …, 2022 - Elsevier
Background and aims Placental lipid transport is altered in women with high prepregnancy
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …

[HTML][HTML] Obesity downregulates lipid metabolism genes in first trimester placenta

A Rasool, T Mahmoud, B Mathyk, T Kaneko-Tarui… - Scientific Reports, 2022 - nature.com
Placentas of obese women have low mitochondrial β-oxidation of fatty acids (FA) and
accumulate lipids in late pregnancy. This creates a lipotoxic environment, impairing …

[HTML][HTML] Effect of maternal obesity with and without gestational diabetes on offspring subcutaneous and preperitoneal adipose tissue development from birth up to year …

K Uebel, K Pusch, K Gedrich, KTM Schneider… - BMC pregnancy and …, 2014 - Springer
Background Maternal obesity and gestational diabetes mellitus (GDM) may independently
influence offspring fat mass and metabolic disease susceptibility. In this pilot study, body …

Foetoplacental epigenetic changes associated with maternal metabolic dysfunction

B Kerr, A Leiva, M Farias, S Contreras-Duarte, F Toledo… - Placenta, 2018 - Elsevier
Metabolic-related diseases are attributed to a sedentary lifestyle and eating habits, and
there is now an increased awareness regarding pregnancy as a preponderant window in …

Effect of maternal obesity on placental lipid metabolism

V Calabuig-Navarro, M Haghiac, J Minium… - …, 2017 - academic.oup.com
Obese women, on average, give birth to babies with high fat mass. Placental lipid
metabolism alters fetal lipid delivery, potentially moderating neonatal adiposity, yet how it is …

[HTML][HTML] Obesity affects maternal and neonatal HDL metabolism and function

JT Stadler, MNM van Poppel, C Wadsack, M Holzer… - Antioxidants, 2023 - mdpi.com
Pregravid obesity is one of the major risk factors for pregnancy complications such as
gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in …

IGF-1 and leptin associate with fetal HDL cholesterol at birth: examination in offspring of mothers with type 1 diabetes

SM Nelson, DJ Freeman, N Sattar, FD Johnstone… - Diabetes, 2007 - Am Diabetes Assoc
OBJECTIVE—Offspring of mothers with type 1 diabetes (OT1DM) demonstrate increased fat
deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of …