Skeletal muscle insulin resistance is a central defect in the pathogenesis of type 2 diabetes
(T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies …

Aims/hypothesis The molecular mechanisms underlying insulin resistance in skeletal
muscle are incompletely understood. Here, we aimed to obtain a global picture of changes …

Introduction: Mitochondria are essential in energy metabolism and cellular survival, and
there is growing evidence that insulin resistance in chronic metabolic disorders, such as …

Abnormal glucose handling has emerged as a major clinical problem in millions of diabetic
patients worldwide. Insulin resistance affects especially one of the main target organs of this …

OBJECTIVE Insulin resistance in skeletal muscle is an early phenomenon in the
pathogenesis of type 2 diabetes. Studies of insulin resistance usually are highly focused …

Introduction: Skeletal muscle is the major site of insulin-stimulated glucose uptake and
imparts the beneficial effects of exercise, and hence is an important site of insulin resistance …

Insulin plays pivotal role in cellular fuel metabolism in skeletal muscle. Despite being the
primary site of energy metabolism, the underlying mechanism on how insulin deficiency …

The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with
mitochondrial functions in insulin-responsive tissues. The mitochondrial proteome …

Aims/hypothesis Mitochondria operate in networks, adapting to external stresses and
changes in cellular metabolic demand and are subject to various quality control …

Exercise is regarded as a potent stimulus in modulation of glucose utility and mitochondrial
adaptations in skeletal muscle, leading to enhanced metabolic health. As mitochondria play …