[图书][B] Chemical Tools to Interrogate and Inhibit Bacterial Exotoxins

MM Garland - 2021 - search.proquest.com
Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the
overprescription of antibiotics as well as a lack of development of new antibacterial agents …

Chemical strategies to target bacterial virulence

M Garland, S Loscher, M Bogyo - Chemical reviews, 2017 - ACS Publications
Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the
overprescription of antibiotics as well as a lack of development of new antibacterial agents …

Disarming the enemy: Targeting bacterial toxins with small molecules

A Huerta-Uribe, AJ Roe - Emerging Topics in Life Sciences, 2017 - portlandpress.com
The rapid emergence of antibiotic-resistant bacterial strains has prompted efforts to find new
and more efficacious treatment strategies. Targeting virulence factors produced by …

Systematic discovery of antibacterial and antifungal bacterial toxins

N Nachmias, N Dotan, R Fraenkel, MC Rocha… - bioRxiv, 2021 - biorxiv.org
Microbes employ a large diversity of toxins to kill competing microbes or eukaryotic host
cells. Polymorphic toxins are a class of protein toxins abundant in Nature and secreted …

General aspects and recent advances on bacterial protein toxins

E Lemichez, JT Barbieri - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Bacterial pathogens produce protein toxins to influence host–pathogen interactions and tip
the outcome of these encounters toward the benefit of the pathogen. Protein toxins modify …

Some Examples of Bacterial Toxins as Tools

G Schmidt - Toxins, 2024 - mdpi.com
Pathogenic bacteria produce diverse protein toxins to disturb the host's defenses. This
includes the opening of epithelial barriers to establish bacterial growth in deeper tissues of …

[PDF][PDF] Systematic Discovery of Antimicrobial Polymorphic Toxins

N Nachmias, N Dotan, M Shalom, A Rivitz… - scholar.archive.org
Microbes employ a large diversity of toxins to kill competing microbes or eukaryotic host
cells. Polymorphic toxins are a class of protein toxins abundant in Nature and secreted …

Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins

K Čapková, NT Salzameda, KD Janda - Toxicon, 2009 - Elsevier
Botulinum neurotoxins (BoNTs), proteins secreted by the bacteria genus Clostridium,
represent a group of extremely lethal toxins and a potential bioterrorism threat. As the …

Novel Therapeutic Agents from Bacterial Toxins

JA Chaddock - 2013 - books.rsc.org
Although it is difficult to arise at a consensus for the number of bacterial species on earth, it
is well understood it represents one of the most diverse groups of living organisms and, from …

Antibacterial toxins: gram-positive bacteria strike back!

A Jamet, A Charbit, X Nassif - Trends in microbiology, 2018 - cell.com
Bacteria live in communities where strains compete with each other by deploying an arsenal
of antibacterial toxins. While the past decade revealed the vast array of antibacterial toxins …