In the past few years, several conventional neuroinflammation-mediated epilepsy models
have been modified to correlate the same with the actual clinical pathophysiological pattern …

Experimental and clinical evidence have demonstrated the increased synthesis of specific
inflammatory mediators, and the upregulation of their cognate receptors in the chronic …

A large body of evidence that has accumulated over the past decade strongly supports the
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …

Unabated neuroinflammation plays a pathogenic role in various CNS diseases. In epilepsy,
neuroinflammation is not a bystander phenomenon of the diseased brain but contributes to …

Background: The lack of treatments which can prevent epilepsy development or improve
disease prognosis represents an unmet and urgent clinical need. The development of such …

The production of inflammatory molecules in the brain has been described after seizure
induction in experimental models as well as in epileptogenic tissue from clinical cases of …

Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

Inflammatory mediators are overexpressed in brain tissue after induction of seizures in
animal models, and several studies demonstrate their involvement in neuronal …

Neuroinflammation and epilepsy are different pathologies, but, in some cases, they are so
closely related that the activation of one of the pathologies leads to the development of the …

As a crucial component of brain innate immunity, neuroinflammation initially contributes to
neuronal tissue repair and maintenance. However, chronic inflammatory processes within …