The galloyl moiety enhances the inhibitory activity of catechins and theaflavins against α-glucosidase by increasing the polyphenol–enzyme binding interactions

L Sun, Y Song, Y Chen, Y Ma, M Fu, X Liu - Food & Function, 2021 - pubs.rsc.org
The inhibition properties of 10 tea polyphenols against α-glucosidase were studied through
inhibition assay, inhibition kinetics, fluorescence quenching and molecular docking. It was …

Number of galloyl moiety and intramolecular bonds in galloyl-based polyphenols affect their interaction with alpha-glucosidase

J Cao, S Yan, Y Xiao, L Han, L Sun, M Wang - Food Chemistry, 2022 - Elsevier
The inhibition of α-glucosidase by nine galloyl-based polyphenols with free and unfree
galloyl moieties (GMs) was studied. The results show that the inhibitory activity increased …

Number of galloyl moieties and molecular flexibility are both important in alpha-amylase inhibition by galloyl-based polyphenols

J Cao, Y Zhang, L Han, S Zhang, X Duan, L Sun… - Food & function, 2020 - pubs.rsc.org
The inhibition of porcine pancreatic α-amylase (PPA) by 9 galloyl-based polyphenols was
evaluated via initial digestion velocity, IC50, inhibition kinetics, fluorescence quenching and …

Young apple polyphenols as natural α-glucosidase inhibitors: In vitro and in silico studies

T Gong, X Yang, F Bai, D Li, T Zhao, J Zhang, L Sun… - Bioorganic …, 2020 - Elsevier
In this study, the inhibitory activity of young apple polyphenols (YAP) on α-glucosidase was
investigated. Composition and inhibition analyses suggested that tannic acid (TA),(-) …

Molecular insights into α‐glucosidase inhibition and antiglycation properties affected by the galloyl moiety in (−)‐epigallocatechin‐3‐gallate

Q Guan, L Tang, L Zhang, L Huang… - Journal of the …, 2023 - Wiley Online Library
BACKGROUND Diabetes mellitus poses a substantial threat to public health due to rising
morbidity and mortality. α‐Glucosidase is one of the key enzymes affecting diabetes …

Inhibitory mechanism of novel allosteric inhibitor, Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins against α-glucosidase

M Wang, J Jiang, J Tian, S Chen, X Ye, Y Hu… - Journal of functional …, 2019 - Elsevier
Abstract α-Glucosidase is a key enzyme related to starch digestion and type-2 diabetes. In
the present study, the inhibition effect and the underlying mechanism of Chinese bayberry …

Studies on the inhibition of α-glucosidase by biflavonoids and their interaction mechanisms

H Li, J Yang, M Wang, X Ma, X Peng - Food Chemistry, 2023 - Elsevier
Biflavonoids are a kind of polyphenol compounds with numerous biological functions.
However, the potential inhibitory activities of biflavonoids on α-glucosidase are yet unknown …

α-Glucosidase inhibitory profile of catechins and theaflavins

T Matsui, T Tanaka, S Tamura, A Toshima… - Journal of agricultural …, 2007 - ACS Publications
To clarify the postprandial glucose suppression effect of flavonoids, the inhibitory effects of
catechins and theaflavins against α-glucosidase (AGH) were examined in this study. It was …

Inhibition of α-glucosidase and α-amylase by flavonoid glycosides from Lu'an GuaPian tea: molecular docking and interaction mechanism

F Hua, P Zhou, HY Wu, GX Chu, ZW Xie, GH Bao - Food & function, 2018 - pubs.rsc.org
Green tea may favorably modulate blood glucose homeostasis, and regular consumption of
green tea can prevent the development of type 2 diabetes mellitus. In this study, α …

Advance in dietary polyphenols as α-glucosidases inhibitors: a review on structure-activity relationship aspect

J Xiao, G Kai, K Yamamoto, X Chen - Critical reviews in food …, 2013 - Taylor & Francis
The dietary polyphenols as α-glucosidases inhibitors have attracted great interest among
researchers. The aim of this review is to give an overview of the research reports on the …