How neurons in the medial prefrontal cortex broadcast stress-relevant information to
subcortical brain sites to regulate cocaine relapse remains unclear. The lateral habenula …

Projections from the lateral habenula (LHb) control ventral tegmental area (VTA) neuronal
populations' activity and both nuclei shape the pathological behaviors emerging during …

Propensity to relapse, even following long periods of abstinence, is a key feature in
substance use disorders. Relapse and relapse‐like behaviors are known to be induced, in …

Addictive substances mediate positive and negative states promoting persistent drug use.
However, substrates for aversive effects of drugs remain elusive. We found that, in mouse …

Addictive drugs share the ability to increase dopamine (DA) levels and trigger synaptic
adaptations in the mesocorticolimbic system, two cellular processes engaged in the early …

Cocaine withdrawal produces aversive states and vulnerability to relapse, hallmarks of
addiction. The lateral habenula (LHb) encodes negative stimuli and contributes to aversive …

Interest in the habenula has greatly increased in recent years. The habenula is a small brain
structure located posterior to the thalamus and adjacent to the third ventricle. Despite its …

The habenula (Hb) is central to adaptive reward-and aversion-driven behaviors, comprising
a hub for higher-order processing networks involving the prefrontal cortex (PFC). Despite an …

The aversive properties associated with drugs of abuse influence both the development of
addiction and relapse. Cocaine produces strong aversive effects after rewarding effects …

Many strong rewards, including abused drugs, also produce aversive effects that are poorly
understood. For example, cocaine can produce aversive conditioning after its rewarding …