Exploring the antivirulence activity of pulverulentone A, a phloroglucinol-derivative from Callistemon citrinus leaf extract, against multi-drug resistant Pseudomonas …

MM Ismail, M Hassan, SS Moawad, MM Okba… - Antibiotics, 2021 - mdpi.com
(1) Background: Bacterial resistance to antibiotics is a global life-threatening issue.
Antivirulence therapy is a promising approach to combat bacterial infections as it disarms …

Coumarin Exhibits Broad-Spectrum Antibiofilm and Antiquorum Sensing Activity against Gram-Negative Bacteria: In Vitro and In Silico Investigation

FA Qais, MS Khan, I Ahmad, FM Husain, RA Khan… - ACS …, 2021 - ACS Publications
Quorum sensing (QS) and biofilm inhibition are recognized as the novel drug targets for the
broad-spectrum anti-infective strategy to combat the infections caused by drug-resistant …

Attenuation of quorum sensing regulated virulence functions and biofilm of pathogenic bacteria by medicinal plant Artemisia annua and its phytoconstituent 1, 8 …

MA Khan, M Shahid, I Celik, HM Khan… - Microscopy …, 2024 - Wiley Online Library
The emergence of multidrug resistance (MDR) in bacterial pathogens is a serious public
health concern. A significant therapeutic target for MDR infections is the quorum sensing …

Adjuvant effect of cranberry proanthocyanidin active fraction on antivirulent property of ciprofloxacin against Pseudomonas aeruginosa

A Vadekeetil, V Alexandar, S Chhibber, K Harjai - Microbial pathogenesis, 2016 - Elsevier
Quorum sensing inhibitors (QSIs) act as antivirulent agents since quorum sensing (QS)
plays a vital role in regulating pathogenesis of Pseudomonas aeruginosa. However …

Inhibition of biofilm formation, quorum sensing and other virulence factors in Pseudomonas aeruginosa by polyphenols of Gynura procumbens leaves

Z Nain, FJ Mansur, SB Syed, MA Islam… - Journal of …, 2022 - Taylor & Francis
Quorum sensing (QS) enables virulence factors in bacteria for biofilm formation and
pathogenic invasion. Therefore, quorum quenching (QQ), disruption of QS circuit, becomes …

Inhibitory Effects of Compounds from Plumula nelumbinis on Biofilm and Quorum Sensing Against P. aeruginosa

H Chen, L Wu, Y Su, Z Huang, L Wang, Z Xia… - Current …, 2022 - Springer
Quorum sensing (QS), which controls the survival and virulence of Pseudomonas
aeruginosa, including the formation of biofilm, is considered to be a new target to overcome …

Quorum Sensing Inhibitory Potential and Molecular Docking Studies of Phyllanthus emblica Phytochemicals Against Pseudomonas aeruginosa

S Baburam, S Ramasamy, G Shanmugam… - Applied Biochemistry …, 2022 - Springer
Phyllanthus emblica is a traditional medicinal plant that is endowed with curative properties
including anti-bacterial, anti-fungal, anti-viral, and analgesic properties. Bacteria make use …

Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions

L Zhong, V Ravichandran, N Zhang, H Wang… - International journal of …, 2020 - mdpi.com
Natural products play vital roles against infectious diseases since ancient times and most
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …

Computational exploration of Picrasma quassioides compounds as CviR-mediated quorum sensing inhibitors against Chromobacterium violaceum

PD Revanasiddappa, G HG, C KP… - Frontiers in …, 2024 - frontiersin.org
Chromobacterium violaceum an opportunistic human pathogenic bacterium, exhibits
resistance to conventional antibiotics by exploiting its quorum sensing mechanism to …

In vivo, in vitro and molecular docking studies reveal the anti-virulence property of hispidulin against Pseudomonas aeruginosa through the modulation of quorum …

VT Anju, S Busi, MS Mohan, S Ranganathan… - International …, 2022 - Elsevier
Pseudomonas aeruginosa is an audacious infectious agent involved in multiple persistent
and incurable diseases in hosts through quorum sensing mediated pathways. Thus …