The application of CRISPR/Cas systems for antiviral therapy
HJE Baddeley, M Isalan - Frontiers in Genome Editing, 2021 - frontiersin.org
As CRISPR/Cas systems have been refined over time, there has been an effort to apply
them to real world problems, such as developing sequence-targeted antiviral therapies …
them to real world problems, such as developing sequence-targeted antiviral therapies …
[HTML][HTML] Harnessing CRISPR technology for viral therapeutics and vaccines: from preclinical studies to clinical applications
F Zahedipour, F Zahedipour, P Zamani, MR Jaafari… - Virus Research, 2024 - Elsevier
The CRISPR/Cas system, identified as a type of bacterial adaptive immune system, have
attracted significant attention due to its remarkable ability to precisely detect and eliminate …
attracted significant attention due to its remarkable ability to precisely detect and eliminate …
Detect and destroy: CRISPR-based technologies for the response against viruses
CA Freije, PC Sabeti - Cell host & microbe, 2021 - cell.com
Despite numerous viral outbreaks in the last decade, including a devastating global
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
Antiviral goes viral: harnessing CRISPR/Cas9 to combat viruses in humans
JA Soppe, RJ Lebbink - Trends in microbiology, 2017 - cell.com
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) systems are RNA-guided sequence-specific prokaryotic antiviral immune …
associated (Cas) systems are RNA-guided sequence-specific prokaryotic antiviral immune …
Engineering CRISPR/Cas13 system against RNA viruses: from diagnostics to therapeutics
Y Xue, Z Chen, W Zhang, J Zhang - Bioengineering, 2022 - mdpi.com
Over the past decades, RNA viruses have been threatened people's health and led to global
health emergencies. Significant progress has been made in diagnostic methods and …
health emergencies. Significant progress has been made in diagnostic methods and …
[HTML][HTML] Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …
CRISPR/Cas9-based antiviral strategy: current status and the potential challenge
C Lee - Molecules, 2019 - mdpi.com
From its unexpected discovery as a bacterial adaptive immune system to its countless
applications as one of the most versatile gene-editing tools, the CRISPR/Cas9 system has …
applications as one of the most versatile gene-editing tools, the CRISPR/Cas9 system has …
[HTML][HTML] The CRISPR/Cas9 genome editing methodology as a weapon against human viruses
MK White, W Hu, K Khalili - Discovery medicine, 2015 - ncbi.nlm.nih.gov
Viruses are a therapeutic challenge since their life cycles occur within the host cells and
often utilize cellular proteins and hence it is harder to identify therapeutic targets compared …
often utilize cellular proteins and hence it is harder to identify therapeutic targets compared …
CRISPR systems: Novel approaches for detection and combating COVID-19
Abstract Type V and VI CRISPR enzymes are RNA-guided, DNA and RNA-targeting
effectors that allow specific gene knockdown. Cas12 and Cas13 are CRISPR proteins that …
effectors that allow specific gene knockdown. Cas12 and Cas13 are CRISPR proteins that …
[HTML][HTML] Harnessing CRISPR to combat human viral infections
H De Buhr, RJ Lebbink - Current Opinion in Immunology, 2018 - Elsevier
Highlights•CRISPR can combat pathogenic human viruses.•Targeting viral DNA directly
abrogates infection and replication.•CRISPR can excise and disrupt integrated viral DNA in …
abrogates infection and replication.•CRISPR can excise and disrupt integrated viral DNA in …