Contemporary studies on aging and longevity have largely overlooked the role that
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Aging is a major risk factor for multiple diseases. Understanding the underlying mechanisms
of aging would help to delay and prevent age-associated diseases. Short-lived model …

Senescence, the functional deterioration of cells or organisms associated with increased
age, is pervasive across the tree of life. Yet our understanding of the genetic and …

The theory that ageing evolves because of competitive resource allocation between the
soma and the germline has been challenged by studies showing that somatic maintenance …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Although lifespan in mammals varies over 100-fold, the precise evolutionary mechanisms
underlying variation in longevity remain unknown. Species-specific genetic changes have …

Mammals differ more than 100‐fold in maximum lifespan, which can be altered in either
direction during evolution, but the molecular basis for natural changes in longevity is not …

In contraposition to the view of aging as a stochastic time-dependent accumulation of
damage, phenoptotic theories of aging postulate that senescence may provide supra …

Explaining why ageing occurs is a solution to the longstanding enigma of the role of
senescence in nature. Even after half a century of progress, this solution continues to unfold …