Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Integrated metabolomic–genomic workflows accelerate microbial natural product discovery
The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …
natural product chemistry. With an increase in the availability of sequencing and assembly of …
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
Covering: 2000 to 2016 The labor-intensive process of microbial natural product discovery is
contingent upon identifying discrete secondary metabolites of interest within complex …
contingent upon identifying discrete secondary metabolites of interest within complex …
The confluence of big data and evolutionary genome mining for the discovery of natural products
This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …
genome mining tools has given rise to ever-growing genetic and chemical databases and …
Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …
organisms and assess their biological properties from either a chemical ecology or drug …
A global approach to analysis and interpretation of metabolic data for plant natural product discovery
M Hur, AA Campbell, M Almeida-de-Macedo… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2013 Discovering molecular components and their functionality is key to the
development of hypotheses concerning the organization and regulation of metabolic …
development of hypotheses concerning the organization and regulation of metabolic …
Microbial natural product databases: moving forward in the multi-omics era
Covering: 2010–2020 The digital revolution is driving significant changes in how people
store, distribute, and use information. With the advent of new technologies around linked …
store, distribute, and use information. With the advent of new technologies around linked …
Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries
Traditional natural products discovery using a combination of live/dead screening followed
by iterative bioassay-guided fractionation affords no information about compound structure …
by iterative bioassay-guided fractionation affords no information about compound structure …
[HTML][HTML] Linking genomics and metabolomics to chart specialized metabolic diversity
JJJ van Der Hooft, H Mohimani… - Chemical Society …, 2020 - pubs.rsc.org
Microbial and plant specialized metabolites constitute an immense chemical diversity, and
play key roles in mediating ecological interactions between organisms. Also referred to as …
play key roles in mediating ecological interactions between organisms. Also referred to as …
[HTML][HTML] Metabolomics-and systems-biology-guided discovery of metabolite lead compounds and druggable targets
A Palermo - Drug Discovery Today, 2023 - Elsevier
Highlights•Metabolomics and systems biology at large can accelerate lead compound
discovery from natural sources.•Systems-level interpretation of omics data aids in the …
discovery from natural sources.•Systems-level interpretation of omics data aids in the …