Extreme longevity has evolved multiple times during the evolution of mammals, yet its
underlying molecular mechanisms remain largely underexplored. Here, we compared the …

Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …

Studies in invertebrate model organisms have been a driving force in aging research,
leading to the identification of many genes that influence life span. Few of these genes have …

The use of genomic technologies in biogerontology has the potential to greatly enhance our
understanding of human ageing. High-throughput screens for alleles correlated with survival …

Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Genes which confer a relative longevity advantage may be regulated at the level of
transcription or translation. Alternatively, pro-longevity genes may mediate their effects at the …

Much of the current research on longevity focuses on the aging process within a single
species. Several molecular players (eg IGF1 and MTOR), pharmacological compounds (eg …

Background To what extent are the determinants of aging in animal species universal?
Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) …