Colon‐targeted adhesive hydrogel microsphere for regulation of gut immunity and flora
H Liu, Z Cai, F Wang, L Hong, L Deng… - Advanced …, 2021 - Wiley Online Library
Intestinal immune homeostasis and microbiome structure play a critical role in the
pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment …
pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment …
Oral delivery of stem-cell-loaded hydrogel microcapsules restores gut inflammation and microbiota
Mesenchymal stem cells (MSCs) are an attractive candidate for the treatment of
inflammatory bowel disease (IBD), but their poor delivery rate to an inflamed colon is a major …
inflammatory bowel disease (IBD), but their poor delivery rate to an inflamed colon is a major …
Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair
F Lei, F Zeng, X Yu, Y Deng, Z Zhang, M Xu… - Journal of …, 2023 - Springer
Background Due to oral nano-delivery systems for the treatment of inflammatory bowel
disease (IBD) are often failed to accumulated to the colonic site and could not achieve …
disease (IBD) are often failed to accumulated to the colonic site and could not achieve …
Poly‐γ‐glutamic acid microgel‐encapsulated probiotics with gastric acid resistance and smart inflammatory factor targeted delivery performance to ameliorate colitis
R Wang, K Guo, W Zhang, Y He, K Yang… - Advanced Functional …, 2022 - Wiley Online Library
Hydrogel microspheres with probiotic‐loaded therapy have been considered an effective
and safe strategy for treating inflammatory bowel disease (IBD). However, the low survival …
and safe strategy for treating inflammatory bowel disease (IBD). However, the low survival …
Calcium Tungstate Microgel enhances the delivery and colonization of Probiotics during Colitis via Intestinal ecological niche occupancy
J Yang, M Peng, S Tan, S Ge, L Xie, T Zhou… - ACS Central …, 2023 - ACS Publications
The effective delivery and colonization of probiotics are recommended for therapeutic
interventions during colitis, the efficacy of which is hampered by abnormally colonized …
interventions during colitis, the efficacy of which is hampered by abnormally colonized …
Modulation of gut barrier functions in ulcerative colitis by hyaluronic acid system
The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are
associated with superficial mucosal damage and intermittent wounding that leads to …
associated with superficial mucosal damage and intermittent wounding that leads to …
Injectable bioadhesive hydrogels scavenging ROS and restoring mucosal barrier for enhanced ulcerative colitis therapy
D Li, J Li, T Chen, X Qin, L Pan, X Lin… - … Applied Materials & …, 2023 - ACS Publications
Despite the progress in the therapy of ulcerative colitis (UC), long-lasting UC remission can
hardly be achieved in the majority of UC patients. The key pathological characteristics of UC …
hardly be achieved in the majority of UC patients. The key pathological characteristics of UC …
Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy
Q Sun, J Chen, Q Zhao, Z He, L Tang, Y Pu… - International Journal of …, 2023 - Elsevier
Ulcerative colitis (UC) as an important type of inflammatory bowel disease is a chronic
disease characterized by intestinal dyshomeostasis. The UC treatment is challenged by the …
disease characterized by intestinal dyshomeostasis. The UC treatment is challenged by the …
An oral pH-activated “nano-bomb” carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease that features
colonic epithelial barrier dysfunction and gut dysbiosis. Preclinical studies demonstrated that …
colonic epithelial barrier dysfunction and gut dysbiosis. Preclinical studies demonstrated that …
Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota
QX Huang, JL Liang, CH Yang, K Li, MT Niu, JX Fan… - Biomaterials, 2023 - Elsevier
Inflammatory bowel disease (IBD) is characterized by the high level of reactive oxygen
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …