Colon‐targeted adhesive hydrogel microsphere for regulation of gut immunity and flora

H Liu, Z Cai, F Wang, L Hong, L Deng… - Advanced …, 2021 - Wiley Online Library
Intestinal immune homeostasis and microbiome structure play a critical role in the
pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment …

Oral delivery of stem-cell-loaded hydrogel microcapsules restores gut inflammation and microbiota

DW Kim, HS Jeong, E Kim, H Lee, CH Choi… - Journal of Controlled …, 2022 - Elsevier
Mesenchymal stem cells (MSCs) are an attractive candidate for the treatment of
inflammatory bowel disease (IBD), but their poor delivery rate to an inflamed colon is a major …

Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair

F Lei, F Zeng, X Yu, Y Deng, Z Zhang, M Xu… - Journal of …, 2023 - Springer
Background Due to oral nano-delivery systems for the treatment of inflammatory bowel
disease (IBD) are often failed to accumulated to the colonic site and could not achieve …

Poly‐γ‐glutamic acid microgel‐encapsulated probiotics with gastric acid resistance and smart inflammatory factor targeted delivery performance to ameliorate colitis

R Wang, K Guo, W Zhang, Y He, K Yang… - Advanced Functional …, 2022 - Wiley Online Library
Hydrogel microspheres with probiotic‐loaded therapy have been considered an effective
and safe strategy for treating inflammatory bowel disease (IBD). However, the low survival …

Calcium Tungstate Microgel enhances the delivery and colonization of Probiotics during Colitis via Intestinal ecological niche occupancy

J Yang, M Peng, S Tan, S Ge, L Xie, T Zhou… - ACS Central …, 2023 - ACS Publications
The effective delivery and colonization of probiotics are recommended for therapeutic
interventions during colitis, the efficacy of which is hampered by abnormally colonized …

Modulation of gut barrier functions in ulcerative colitis by hyaluronic acid system

NG Kotla, ILM Isa, S Rasala, S Demir… - Advanced …, 2022 - Wiley Online Library
The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are
associated with superficial mucosal damage and intermittent wounding that leads to …

Injectable bioadhesive hydrogels scavenging ROS and restoring mucosal barrier for enhanced ulcerative colitis therapy

D Li, J Li, T Chen, X Qin, L Pan, X Lin… - … Applied Materials & …, 2023 - ACS Publications
Despite the progress in the therapy of ulcerative colitis (UC), long-lasting UC remission can
hardly be achieved in the majority of UC patients. The key pathological characteristics of UC …

Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy

Q Sun, J Chen, Q Zhao, Z He, L Tang, Y Pu… - International Journal of …, 2023 - Elsevier
Ulcerative colitis (UC) as an important type of inflammatory bowel disease is a chronic
disease characterized by intestinal dyshomeostasis. The UC treatment is challenged by the …

An oral pH-activated “nano-bomb” carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis

M Yang, C Yang, Y Zhang, X Yan, Y Ma, Y Zhang… - Biomaterials …, 2022 - pubs.rsc.org
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease that features
colonic epithelial barrier dysfunction and gut dysbiosis. Preclinical studies demonstrated that …

Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota

QX Huang, JL Liang, CH Yang, K Li, MT Niu, JX Fan… - Biomaterials, 2023 - Elsevier
Inflammatory bowel disease (IBD) is characterized by the high level of reactive oxygen
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …