Traumatic experiences during development are associated with an increased risk of
developing psychosis. Individuals with psychosis also report a higher rate of past trauma …

The epidemiology and psychology of PTSD noted above is not often considered in
neurobiological models of PTSD. Neurobiological models tend to focus on symptoms. This is …

Animal models of psychiatric disorders are powerful research tools that allow for the
identification of circuits, molecular processes, and behavioral mechanisms through which …

Early-life stress, such as childhood maltreatment, is a well-known etiological factor in
psychopathology, including psychosis. Exposure to early-life stress disrupts the …

The neurobiology and development of treatments for stress-related neuropsychiatric
disorders rely heavily on animal models. However, the complexity of these disorders makes …

Early life adversity is a well-documented risk factor for developmental psychopathology.
While there is no substitute for directly studying human populations with early experience …

Current research suggests that short-term neurobiological adaptations to early traumatic
stress such as child sexual and/or physical abuse may result in long-term alterations of brain …

Traumatic experiences early in life predispose animals and humans to later cognitive-
behavioral, emotional, and somatic problems. In humans, traumatic experiences are strong …

Background A higher incidence of childhood trauma (CT) has been reported in first episode
of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect …

Nusslock and Miller (1) present an integrative model to explain the complex associations
between early-life adversity and subsequent development of psychopathology and physical …