Skeletal muscle mitochondria are placed in close proximity of the sarcoplasmic reticulum
(SR), the main intracellular Ca 2+ store. During muscle activity, excitation of sarcolemma …

Muscle uses Ca 2+ as a messenger to control contraction and relies on ATP to maintain the
intracellular Ca 2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP …

Mitochondria are characterized by a high capacity to accumulate calcium thanks to the
electrochemical gradient created by the extrusion of protons in the respiratory chain …

Recent discoveries of the molecular identity of mitochondrial Ca 2+ influx/efflux mechanisms
have placed mitochondrial Ca 2+ transport at center stage in views of cellular regulation in …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

The notion of mitochondria being involved in the decoding and shaping of intracellular Ca2+
signals has been circulating since the end of the 19th century. Despite that, the molecular …

Ca2+ is an integral component of the functional and developmental regulation of the
mitochondria. In skeletal muscle, Ca2+ is reported to modulate the rate of ATP resynthesis …

ABSTRACT Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like
Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell …

Mitochondrial Ca 2+ uptake regulates a wide array of cell functions, from stimulation of
aerobic metabolism and ATP production in physiological settings, to induction of cell death …

Skeletal muscle mitochondria readily accumulate Ca2+ in response to SR store-releasing
stimuli thanks to the activity of the mitochondrial calcium uniporter (MCU), the highly …