Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated
SLN Maas, D Stichel, T Hielscher, P Sievers… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis
Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …
Prognostic impact of genetic alterations and methylation classes in meningioma
AS Berghoff, T Hielscher, G Ricken, J Furtner… - Brain …, 2022 - Wiley Online Library
Meningiomas are classified based on histological features, but genetic and epigenetic
features are emerging as relevant biomarkers for outcome prediction and may supplement …
features are emerging as relevant biomarkers for outcome prediction and may supplement …
A molecularly integrated grade for meningioma
Background Meningiomas are the most common primary intracranial tumor in adults.
Clinical care is currently guided by the World Health Organization (WHO) grade assigned to …
Clinical care is currently guided by the World Health Organization (WHO) grade assigned to …
Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies
JC Bayley, CC Hadley, AO Harmanci, AS Harmanci… - Science …, 2022 - science.org
One-fifth of meningiomas classified as benign by World Health Organization (WHO)
histopathological grading will behave malignantly. To better diagnose these tumors, several …
histopathological grading will behave malignantly. To better diagnose these tumors, several …
Towards molecular classification of meningioma: evolving treatment and diagnostic paradigms
DT Proctor, S Ramachandran, S Lama… - World neurosurgery, 2018 - Elsevier
Highlights•WHO grading of meningioma may not reflect tumor biology.•Molecular
characterization of meningioma may more closely correlate to tumor biology.•Genetic …
characterization of meningioma may more closely correlate to tumor biology.•Genetic …
[HTML][HTML] Classification of meningiomas—advances and controversies
Meningiomas are the most frequent primary central nervous system (CNS) tumors. Although
approximately 80% of the tumors are slow growing and benign, some subtypes are …
approximately 80% of the tumors are slow growing and benign, some subtypes are …
Genomic landscape of meningiomas
Y Lee, J Liu, S Patel, T Cloughesy, A Lai… - Brain …, 2010 - Wiley Online Library
Meningiomas are one of the most common adult brain tumors. For most patients, surgical
excision is curative. However, up to 20% recur. Currently, the molecular determinants …
excision is curative. However, up to 20% recur. Currently, the molecular determinants …
Advances in meningioma genetics: novel therapeutic opportunities
M Preusser, PK Brastianos, C Mawrin - Nature Reviews Neurology, 2018 - nature.com
Meningiomas currently are among the most frequent intracranial tumours. Although the
majority of meningiomas can be cured by surgical resection,∼ 20% of patients have an …
majority of meningiomas can be cured by surgical resection,∼ 20% of patients have an …
Proposal for a new risk stratification classification for meningioma based on patient age, WHO tumor grade, size, localization, and karyotype
PH Domingues, P Sousa, A Otero… - Neuro …, 2014 - academic.oup.com
Background Tumor recurrence remains the major clinical complication of meningiomas, the
majority of recurrences occurring among WHO grade I/benign tumors. In the present study …
majority of recurrences occurring among WHO grade I/benign tumors. In the present study …