Differentiation of naïve peripheral B cells into terminally differentiated plasma cells is
characterized by epigenetic alterations, yet the epigenetic mechanisms that control B‐cell …

Cytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic
mechanisms control lymphocyte development has not been well defined. Here we show that …

Histone modifiers are essential for the ability of immune cells to reprogram their gene
expression during differentiation. The recruitment of the histone methyltransferase DOT1L …

DOT1-Like (DOT1L) is the sole methyltransferase of histone H3K79, a modification enriched
mainly on the bodies of actively transcribing genes. DOT1L has been extensively studied in …

Actively transcribed genes in mammals are decorated by H3K79 methylation, which is
correlated with transcription levels and is catalyzed by the histone methyltransferase DOT1L …

DOT1L is essential for embryonic hematopoiesis but the precise mechanisms of its action
remain unclear. The only recognized function of DOT1L is histone H3 lysine 79 (H3K79) …

Mouse embryonic stem cells (ESCs) proliferate with rapid cell cycle kinetics but without loss
of pluripotency. The histone methyltransferase Dot1L is responsible for methylation of …

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine
79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects …

Methylation of lysines within histone proteins represents a posttranslational modification
system that can have profound effects on gene expression. An evolutionarily conserved, but …

Disruptor of telomeric silencing 1 (DOT1) was first identified in yeast (DOT1p) and is the sole
methyltransferase responsible for histone three lysine 79 (H3K79) mono-, di-, and tri …