Sestrin2 is a highly conserved protein that can be induced under a variety of stress
conditions, including DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and …

Sestrin proteins have been implicated in multiple biological processes including resistance
to oxidative and genotoxic stresses, protection against aging-related pathologies, and …

Sestrin2 is a stress‐inducible metabolic regulator and a conserved antioxidant protein which
has been implicated in the pathogenesis of several diseases. Sestrin2 can protect against …

Sestrin2 (SESN2), a highly conserved stress‐inducible metabolic protein, is known to
repress reactive oxygen species (ROS) and provide cytoprotection against various noxious …

Sestrins represent a family of stress-inducible proteins that prevent the progression of many
age-and obesity-associated disorders. Endogenous Sestrins maintain insulin-dependent …

Sestrin2 is a conserved antioxidant, metabolism regulator, and downstream of P53. Sestrin2
can suppress oxidative stress and inflammation, thereby preventing the development and …

Chronic activation of mammalian target of rapamycin complex 1 (mTORC1) and p70 S6
kinase (S6K) in response to hypernutrition contributes to obesity-associated metabolic …

Sestrin2 is a stress-inducible protein that functions as an antioxidant and inhibitor of mTOR
complex 1. In a recent study, we found that Sestrin2 overexpression in brown adipocytes …

Impaired insulin-stimulated glucose uptake in skeletal muscle serves a critical role in the
development of insulin resistance (IR), whereas the precise mechanism of the process …

Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting
stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia …