The role of inflammatory mediators in epilepsy: focus on developmental and epileptic encephalopathies and therapeutic implications

A Orsini, T Foiadelli, G Costagliola, A Michev… - Epilepsy Research, 2021 - Elsevier
In recent years, there has been an increasing interest in the potential involvement of
neuroinflammation in the pathogenesis of epilepsy. Specifically, the role of innate immunity …

[HTML][HTML] Neuroinflammation in epileptogenesis: from pathophysiology to therapeutic strategies

W Li, J Wu, Y Zeng, W Zheng - Frontiers in Immunology, 2023 - frontiersin.org
Epilepsy is a group of enduring neurological disorder characterized by spontaneous and
recurrent seizures with heterogeneous etiology, clinical expression, severity, and prognosis …

Experimental studies in epilepsy: immunologic and inflammatory mechanisms

A Legido, CD Katsetos - Seminars in pediatric neurology, 2014 - Elsevier
In this article, we review the literature based on experimental studies lending credence to a
relationship between epilepsy and immune-mediated mechanisms linked to central nervous …

Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

EA van Vliet, E Aronica, A Vezzani… - Neuropathology and …, 2018 - Wiley Online Library
Accumulating evidence indicates an important pathophysiological role of brain inflammation
in epilepsy. In this review, we will provide an update of specific inflammatory pathways that …

Does brain inflammation mediate pathological outcomes in epilepsy?

KS Wilcox, A Vezzani - Issues in Clinical Epileptology: A View from the …, 2014 - Springer
Inflammation in the central nervous system (CNS) is associated with epilepsy and is
characterized by the increased levels of a complex set of soluble molecules and their …

Neuroinflammatory mediators in acquired epilepsy: an update

Y Chen, MM Nagib, N Yasmen, MN Sluter… - Inflammation …, 2023 - Springer
Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

The role of inflammation in epilepsy

A Vezzani, J French, T Bartfai, TZ Baram - Nature reviews neurology, 2011 - nature.com
Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

Immunity and inflammation in epilepsy

A Vezzani, B Lang, E Aronica - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
This review reports the available evidence on the activation of the innate and adaptive
branches of the immune system and the related inflammatory processes in epileptic …

Chemokines as new inflammatory players in the pathogenesis of epilepsy

C Cerri, M Caleo, Y Bozzi - Epilepsy Research, 2017 - Elsevier
A large series of clinical and experimental studies supports a link between inflammation and
epilepsy, indicating that inflammatory processes within the brain are important contributors …

Role of inflammatory mediators in the pathogenesis of epilepsy

T Shimada, T Takemiya, H Sugiura… - Mediators of …, 2014 - Wiley Online Library
Epilepsy is one of the most common chronic brain disorders worldwide, affecting 1% of
people across different ages and backgrounds. Epilepsy is defined as the sporadic …