Interleukin-1β in peripheral monocytes is associated with seizure frequency in pediatric drug-resistant epilepsy

G Yamanaka, T Takamatsu, S Morichi… - Journal of …, 2021 - Elsevier
In this study, we assessed circulating immune cells and plasma cytokine levels in 15
pediatric patients with drug-resistant epilepsy (DRE). DRE patients had a significantly higher …

[HTML][HTML] Increased production of inflammatory cytokines by circulating monocytes in mesial temporal lobe epilepsy: A possible role in drug resistance

C Milano, M Montali, S Barachini, IS Burzi… - Journal of …, 2024 - Elsevier
We analyzed peripheral blood mononuclear cells (PBMCs) and serum inflammatory
biomarkers in patients with mesial temporal lobe epilepsy (drug-resistant–DR, vs. drug …

Cytokine production in blood mononuclear cells from epileptic patients

R Pacifici, L Paris, S Di Carlo, A Bacosi, S Pichini… - …, 1995 - Wiley Online Library
Although convulsive disorders have been associated with immune abnormalities, little is
known about cytokine production in epileptic patients. We evaluated the concentrations of …

The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients

J Hulkkonen, E Koskikallio, S Rainesalo, T Keränen… - Epilepsy research, 2004 - Elsevier
Purpose: Excessive neuronal activity and seizures directly stimulate cytokine expression. In
this study we investigated cytokine production in circulating blood and peripheral blood …

[HTML][HTML] Temporal lobe epilepsy: Evaluation of central and systemic immune-inflammatory features associated with drug resistance.

A Toledo, S Orozco-Suárez, M Rosetti, L Maldonado… - Seizure, 2021 - Elsevier
Neuroinflammation is probably one of the factors involved in drug resistance in people with
epilepsy. Finding peripheral markers reflecting the intensity of neuroinflammation could be …

Do cytokines have any role in epilepsy?

S Sinha, SA Patil, V Jayalekshmy, P Satishchandra - Epilepsy Research, 2008 - Elsevier
OBJECTIVE: We analyzed cytokines levels in patients with epilepsy and new onset seizure
and correlated it various parameters. MATERIALS AND METHODS: After obtaining consent …

Increased frequency of proinflammatory CD4 T cells and pathological levels of serum neurofilament light chain in adult drug‐resistant epilepsy

O Ouédraogo, RM Rébillard, H Jamann… - …, 2021 - Wiley Online Library
Objective Adult drug‐resistant epilepsy (DRE) is associated with significant morbidity.
Infiltration of immune cells is observed in DRE epileptic foci; however, the relation between …

NK and CD4+ T cell changes in blood after seizures in temporal lobe epilepsy

S Bauer, M Köller, S Cepok, A Todorova-Rudolph… - Experimental …, 2008 - Elsevier
Immunological phenomena may affect the course of focal epilepsy. We analyzed
prospectively the pre-and postictal distribution of leukocyte subsets in epileptic patients …

[HTML][HTML] Increased interleukin-6 and high-sensitivity C-reactive protein levels in pediatric epilepsy patients with frequent, refractory generalized motor seizures

N Ishikawa, Y Kobayashi, Y Fujii, M Kobayashi - Seizure, 2015 - Elsevier
Purpose Recently, it was found that chronic inflammation contributes to the pathomechanism
of diverse chronic diseases in various organs. There is accumulating evidence that …

Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy

S Liimatainen, M Fallah, E Kharazmi, M Peltola… - Journal of …, 2009 - Springer
Previous studies have reported activation of inflammatory cytokines in seizures, but clinical
characteristics of epilepsy associated with cytokine activation have not been well …