[引用][C] Evaluation of transposon-derived regulation in breast cancer
J Jiang - 2021 - espace.library.uq.edu.au
Cancer development often involves extensive alterations in the transcriptome. Transposons,
which are repetitive DNA elements occupying 45% of the human genome, are typically …
which are repetitive DNA elements occupying 45% of the human genome, are typically …
L1PA2 transposons contribute abundant regulatory sequences in MCF7 breast cancer cell line
Transposons, a type of repetitive DNA elements, can contribute cis-regulatory sequences
and regulate the expression of human genes. L1PA2 is a hominoid-specific subfamily of …
and regulate the expression of human genes. L1PA2 is a hominoid-specific subfamily of …
[HTML][HTML] Integrated transcription factor profiling with transcriptome analysis identifies L1PA2 transposons as global regulatory modulators in a breast cancer model
While transposons are generally silenced in somatic tissues, many transposons escape
epigenetic repression in epithelial cancers, become transcriptionally active and contribute to …
epigenetic repression in epithelial cancers, become transcriptionally active and contribute to …
[HTML][HTML] Widespread exaptation of L1 transposons for transcription factor binding in breast cancer
L1 transposons occupy 17% of the human genome and are widely exapted for the
regulation of human genes, particularly in breast cancer, where we have previously shown …
regulation of human genes, particularly in breast cancer, where we have previously shown …
[HTML][HTML] Human transposons are an abundant supply of transcription factor binding sites and promoter activities in breast cancer cell lines
Background Transposable elements (TE) are commonly regarded as “junk DNA” with no
apparent regulatory roles in the human genome. However, a growing body of evidence …
apparent regulatory roles in the human genome. However, a growing body of evidence …
To Build or To Break: The Dual Impact of Interspersed Transposable Elements in Cancer
DA Moreira, CA de Lanna, JGV da Cruz… - … Structure, Function and …, 2021 - Springer
Transposable elements (TEs) are sequences capable of “jumping” from one point to another
in our DNA through different mechanisms. These genetic elements make up most of our …
in our DNA through different mechanisms. These genetic elements make up most of our …
Enhanced transposable elements
G Brewer - Nature Reviews Cancer, 2023 - nature.com
Enhanced transposable elements | Nature Reviews Cancer Skip to main content Thank you
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Transposable elements in human cancers by genome-wide EST alignment
DS Kim, JW Huh, HS Kim - Genes & genetic systems, 2007 - jstage.jst.go.jp
Transposable elements may affect coding sequences, splicing patterns, and transcriptional
regulation of human genes. Particles of the transposable elements have been detected in …
regulation of human genes. Particles of the transposable elements have been detected in …
[HTML][HTML] TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data
Background Next generation sequencing approaches applied to the analyses of transposon
insertion junction fragments generated in high throughput forward genetic screens has …
insertion junction fragments generated in high throughput forward genetic screens has …
Towards targeting Transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …