Imbalances in redox homeostasis can result in oxidative stress, which is implicated in
various pathological conditions including the fatal neuromuscular disease Duchenne …

In recent years, growing evidence has suggested a prominent role of oxidative stress in the
pathophysiology of several early-and adult-onset muscle disorders, although effective …

Significance: Skeletal muscles have a robust regenerative capacity in response to acute and
chronic injuries. Muscle repair and redox homeostasis are intimately linked; increased …

Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an
X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by …

Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we
discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (Nox2) …

The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective
factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and …

Age-related loss of skeletal muscle mass and contractile dysfunction, or sarcopenia, reduces
independence and quality of life in the elderly and leads to increased risk of comorbidities …

Duchenne muscular dystrophy (DMD) is a genetic progressive muscle-wasting disorder that
leads to rapid loss of mobility and premature death. The absence of functional dystrophin in …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

The progressive and generalized loss of skeletal muscle mass and function, also known as
sarcopenia, underlies disability, increasing adverse outcomes and poor quality of life in …