DNA methylation is a critical regulatory mechanism implicated in development, learning,
memory, and disease in the human brain. Here we have elucidated DNA methylation …

Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …

The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and
function, during normal and pathological brain development and aging remains unclear …

Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …

DNA methylation has been traditionally viewed as a highly stable epigenetic mark in
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …

DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …

The brain is built from a large number of cell types which have been historically classified
using location, morphology and molecular markers. Recent research suggests an important …

Cytosine DNA methylation is a stable epigenetic modification with established roles in
regulating transcription, imprinting, female X-chromosome inactivation, and silencing of …

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …

How do epigenetic modifications change across species and how do these modifications
affect evolution? These are fundamental questions at the forefront of our evolutionary …