Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

Activation of hepatic stellate cells (HSCs) and their trans-differentiation towards collagen-
secreting myofibroblasts (MFB) promote liver fibrosis progression. During chronic liver …

Liver fibrosis occurs in response to any etiology of chronic liver injury including hepatitis B
and C, alcohol consumption, fatty liver disease, cholestasis, and autoimmune hepatitis …

Background & Aims: Following hepatic injury, hepatic stellate cells (HSCs) transdifferentiate
to become extracellular matrix-producing myofibroblasts and to promote hepatic …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Hepatic fibrosis is a wound-healing response to chronic liver injury, which if persistent can
lead to cirrhosis and liver failure. Activation of hepatic stellate cells (HSCs), leading to …

Background & Aims Development of liver fibrosis is associated with activation of quiescent
hepatic stellate cells (HSCs) into collagen type I–producing myofibroblasts (activated HSCs) …

The burden of chronic liver disease is globally increasing at an alarming rate. Chronic liver
injury leads to liver inflammation and fibrosis (LF) as critical determinants of long-term …

Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …

Liver fibrosis is a wound-healing response generated against an insult to the liver that
causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may …