Adverse outcome pathways (AOPs) help to organize available mechanistic information
related to an adverse outcome into key events (KEs) spanning all organizational levels of a …

In the absence of epidemiological data, there is a need to develop computational models
that convert in vitro findings to human disease risk predictions following toxicant exposure. In …

Abstract 3D reconstituted respiratory epithelia have emerged as better in␣ vitro models for
toxicological testing compared to cell lines due to the conservation of key morphological …

Mucociliary clearance is an important primary innate defense mechanism that protects the
lungs from deleterious effects of inhaled pollutants, allergens, and pathogens. Mucociliary …

Exposure to cigarette smoke (CS) is strongly associated with impaired mucociliary clearance
(MCC), which has been implicated in the pathogenesis of CS-induced respiratory diseases …

Respiratory mucociliary clearance (MCC) is a key defense mechanism that functions to
entrap and transport inhaled pollutants, particulates, and pathogens away from the lungs …

Objective: Mucociliary clearance sustains a baseline functionality and an “on demand”
capability to upregulate clearance upon irritant exposure involving mucus hypersecretion …

Respiratory tissues are bombarded by billions of particles daily. If allowed to accumulate,
these particles can cause injury, inflammation, or infection, and thus may significantly disrupt …

Respiratory tract toxicity represents a significant cause of attrition of inhaled drug candidates
targeting respiratory diseases. One of the key issues to allow early detection of respiratory …

Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway
inflammation, airway hyperresponsiveness and airway structural changes (known as …