DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …

Genetic association studies provide evidence for a substantial polygenic component to
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …

Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic …

Emerging evidence suggests that schizophrenia (SZ) susceptibility involves variation at
genetic, epigenetic and transcriptome levels. We describe an integrated approach that …

DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …

Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …

Importance DNA methylation may play an important role in schizophrenia (SZ), either
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …

DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …

Importance Epigenetic studies present unique opportunities to advance schizophrenia
research because they can potentially account for many of its clinical features and suggest …

Schizophrenia is a severe psychiatric disease affecting about 1% of the world's population,
with significant effects on patients and society. Genetic studies have identified several …