The development and homeostasis of vertebrate organisms depend on the “tree of life”, in
other words, the intricate network of vascular tubes composed of endothelial cells attached …

In the context of the vascular system, cell-cell adhesion is of paramount importance, as
demonstrated by the fact that the inhibition of this process during embryogenesis is usually …

Endothelial cell–cell junctions must perform seemingly incompatible tasks during vascular
development—providing stable connections that prevent leakage, while allowing dynamic …

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is prevalent
both during normal mammalian development and in certain pathological conditions such as …

Capillaries provide a vast interface between the blood and the tissues that is crucial for
regulating nutrient delivery, blood coagulation and transmigration of leukocytes to sites of …

Acquisition of new genes encoding for extracellular matrix (ECM) proteins and their cognate
integrin adhesive receptors, as well as secreted pro-and anti-angiogenic factors, proved to …

Adhesion of endothelial cells (ECs) to one another and to the extracellular matrix is
mediated by various surface receptors These surface receptors belong to several families of …

The past two decades of angiogenesis research have identified a wealth of pro-and
antiangiogenic signals originating from the tissue environment, which control blood vessel …

Vascular development requires correct interactions among endothelial cells, pericytes and
surrounding cells. These interactions involve many cell adhesion interactions, including cell …

Mural cells are essential components of blood vessels and are necessary for normal
development, homeostasis, and organ function. Alterations in mural cell density or the stable …