At chemical synapses, neurotransmitters are packaged into synaptic vesicles that release
their contents in response to depolarization. Despite its central role in synaptic function …

To ensure precise neurotransmission and prevent neurotoxic accumulation, l-glutamate
(Glu), the major excitatory neurotransmitter in the brain, is cleared from the synapse by …

Synaptic vesicle release properties vary between neuronal cell types, but in most cases the
molecular basis of this heterogeneity is unknown. Here, we compare in vivo synaptic …

Three subtypes of vesicular transporters accumulate glutamate into synaptic vesicles to
promote its vesicular release. One of the subtypes, VGLUT3, is expressed in neurons …

The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles.
Three isoforms of VGLUT have been identified in humans, but their functional differences …

Synaptic vesicles accumulate neurotransmitters, enabling the quantal release by exocytosis
that underlies synaptic transmission. Specific neurotransmitter transporters are responsible …

Glia and accessory cells regulate the microenvironment around neurons and primary
sensory cells. However, the impact of specific glial regulators of ions and solutes on …

Members of the superfamily of solute carrier (SLC) transmembrane proteins transport
diverse substrates across distinct cellular membranes. Three SLC protein families transport …

Concentration of neurotransmitter inside synaptic vesicles (SVs) underlies the quantal
nature of synaptic transmission. In contrast to many transporters, SV uptake of the principal …

Steady axonal cargo flow is central to the functioning of healthy neurons. However, a
substantial fraction of cargo in axons remains stationary up to several minutes. We examine …