Persistent activation of fibroblasts and resistance of myofibroblasts to turnover play important
roles in organ-tissue fibrosis development and progression. The mechanism that mediates …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease, and the
molecular mechanisms remain poorly understood. Our findings demonstrated that pyruvate …

Disruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within
tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are …

Myofibroblasts are the major cellular source of collagen, and their accumulation—via
differentiation from fibroblasts and resistance to apoptosis—is a hallmark of tissue fibrosis …

Fibrosis following tissue injury is distinguished from normal repair by the accumulation of
pathogenic and apoptosis-resistant myofibroblasts (MFs), which arise primarily by …

Background The expression of pyruvate kinase muscle 2 (PKM2) is augmented in
macrophages of patients with atherosclerotic coronary artery disease. The role of PKM2 in …

Rationale: Fibrosis is a pathologic condition of abnormal accumulation of collagen fibrils.
Collagen is a major extracellular matrix (ECM) protein synthesized and secreted by …

Recent studies indicate that glucose metabolism is altered in rheumatoid arthritis. We
hypothesize that Pkm2, as a key regulatory enzyme of glycolysis pathway, triggers the …

An injured skin is rapidly restored in a manner of wound healing. We have previously shown
that intact insulin signaling and glucose uptake are fundamental to proper wound closure …

During lung fibrosis, the epithelium induces signaling to underlying mesenchyme to
generate excess myofibroblasts and extracellular matrix; herein, we focus on signaling in the …