Microfluidics applications for high-throughput single cell sequencing

W Zhou, Y Yan, Q Guo, H Ji, H Wang, T Xu… - Journal of …, 2021 - Springer
The inherent heterogeneity of individual cells in cell populations plays significant roles in
disease development and progression, which is critical for disease diagnosis and treatment …

Methods and platforms for analysis of nucleic acids from single-cell based on microfluidics

L Liu, X Dong, Y Tu, G Miao, Z Zhang, L Zhang… - Microfluidics and …, 2021 - Springer
Single-cell nucleic acid analysis aims at discovering the genetic differences between
individual cells which is well known as the cellular heterogeneity. This technology facilitates …

Single-cell assay on microfluidic devices

Q Huang, S Mao, M Khan, JM Lin - Analyst, 2019 - pubs.rsc.org
Advances in microfluidic techniques have prompted researchers to study the inherent
heterogeneity of single cells in cell populations. This would be helpful in the identification of …

Recent advances in the use of microfluidic technologies for single cell analysis

TW Murphy, Q Zhang, LB Naler, S Ma, C Lu - Analyst, 2018 - pubs.rsc.org
The inherent heterogeneity in cell populations has become of great interest and importance
as analytical techniques have improved over the past decades. With the advent of …

Microfluidic single cell analysis: from promise to practice

V Lecault, AK White, A Singhal, CL Hansen - Current opinion in chemical …, 2012 - Elsevier
Methods for single-cell analysis are critical to revealing cell-to-cell variability in biological
systems, especially in cases where relevant minority cell populations can be obscured by …

Microfluidics for single cell analysis

H Yin, D Marshall - Current opinion in biotechnology, 2012 - Elsevier
Substantial evidence shows that the heterogeneity of individual cells within a genetically
identical population can be critical to their chance of survival. Methods that use average …

Platforms for single-cell collection and analysis

L Valihrach, P Androvic, M Kubista - International journal of molecular …, 2018 - mdpi.com
Single-cell analysis has become an established method to study cell heterogeneity and for
rare cell characterization. Despite the high cost and technical constraints, applications are …

Recent advances in single cell manipulation and biochemical analysis on microfluidics

D Gao, F Jin, M Zhou, Y Jiang - Analyst, 2019 - pubs.rsc.org
Single cell analysis has become of great interest with unprecedented capabilities for the
systematic investigation of cell-to-cell variation in large populations. Rapid and multi …

The single-cell sequencing: new developments and medical applications

X Tang, Y Huang, J Lei, H Luo, X Zhu - Cell & bioscience, 2019 - Springer
Single-cell sequencing technologies can be used to detect the genome, transcriptome and
other multi-omics of single cells. They can show the differences and evolutionary …

Microfluidic single‐cell multiomics analysis

X Xu, Q Zhang, M Li, S Lin, S Liang, L Cai, H Zhu, R Su… - View, 2023 - Wiley Online Library
Cellular heterogeneity is essential to biological processes, such as embryonic development,
cell differentiation, and the progression of disease. Recent years have seen the …