Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with
chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive …

Cathepsin S (CatS) is upregulated in the lungs of patients with cystic fibrosis (CF). However,
its role in CF lung disease pathogenesis remains unclear. In this study, β-epithelial Na+ …

Cathepsin S (Cat S) is predominantly expressed in antigen-presenting cells and is up-
regulated in several preclinical models of antigen-induced inflammation, suggesting a role …

Background Lung fibrosis is a devastating pulmonary disorder characterized by alveolar
epithelial injury, extracellular matrix deposition and scar tissue formation. Due to its potent …

Cathepsin K (CatK), contributes to the development of chronic lung disease in newborn
infants, but the impact of CatK for the lungs may be multifaceted. We have previously …

Methods: Cat C gene-deficient (CatC), heterozygote (CatC) and wild-type (CatC) mice
received daily exposure to cigarette smoke

Cigarette smoking has marked effects on lung tissue, including induction of oxidative stress,
inflammatory cell recruitment, and a protease/antiprotease imbalance. These effects …

Background Cathepsin K, a cysteine protease predominantly expressed in osteoclasts, is a
major drug target for the treatment of osteoporosis. Recent findings, however, indicate that …

Rationale: Mast cells and neutrophils are key contributors to the pathophysiological
inflammatory processes that underpin asthma and chronic obstructive pulmonary disease …

Background: Cigarette smoking induces molecular changes within the lung, including
oxidative stress, inflammatory cell recruitment and a protease/anti-protease imbalance …