Depressed β‐adrenergic inotropic responsiveness and intracellular calcium handling abnormalities in Duchenne Muscular Dystrophy patients' induced pluripotent …

LN Mekies, D Regev, B Eisen… - Journal of Cellular …, 2021 - Wiley Online Library
Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is an X‐
linked disease affecting male and rarely adult heterozygous females, resulting in death by …

Electrophysiological abnormalities in induced pluripotent stem cell‐derived cardiomyocytes generated from Duchenne muscular dystrophy patients

B Eisen, R Ben Jehuda, AJ Cuttitta… - Journal of Cellular …, 2019 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is an X‐linked progressive muscle degenerative
disease, caused by mutations in the dystrophin gene and resulting in death because of …

Stem cell–derived cardiomyocytes and beta-adrenergic receptor blockade in Duchenne muscular dystrophy cardiomyopathy

F Kamdar, S Das, W Gong, A Klaassen Kamdar… - Journal of the American …, 2020 - jacc.org
Background Although cardiomyopathy has emerged as a leading cause of death in
Duchenne muscular dystrophy (DMD), limited studies and therapies have emerged for …

[HTML][HTML] Bioenergetic and metabolic impairments in induced pluripotent stem cell-derived cardiomyocytes generated from Duchenne muscular dystrophy patients

L Willi, I Abramovich, J Fernandez-Garcia… - International journal of …, 2022 - mdpi.com
Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and
dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in DMD patients …

[HTML][HTML] DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology

S Jelinkova, A Vilotic, J Pribyl, F Aimond… - … in bioengineering and …, 2020 - frontiersin.org
Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by the lack
of functional dystrophin. DMD is associated with progressive dilated cardiomyopathy …

Generation of induced pluripotent stem cells from patients with Duchenne muscular dystrophy and their induction to cardiomyocytes

A Hashimoto, AT Naito, JK Lee… - International Heart …, 2016 - jstage.jst.go.jp
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene which
encodes dystrophin protein. Dystrophin defect affects cardiac muscle as well as skeletal …

Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy

B Lin, Y Li, L Han, AD Kaplan, Y Ao… - Disease models & …, 2015 - journals.biologists.com
Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene (DMD),
and is characterized by progressive weakness in skeletal and cardiac muscles. Currently …

[HTML][HTML] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes

M Sato, N Shiba, D Miyazaki, Y Shiba… - Biochemical and …, 2019 - Elsevier
Duchenne muscular dystrophy (DMD) is a devastating muscle disorder caused by frameshift
mutations in the DMD gene. DMD involves cardiac muscle, and the presence of ventricular …

[HTML][HTML] The intracellular Ca2+ concentration is elevated in cardiomyocytes differentiated from hiPSCs derived from a Duchenne muscular dystrophy patient

F Tsurumi, S Baba, D Yoshinaga, K Umeda, T Hirata… - PLoS …, 2019 - journals.plos.org
Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular
dystrophy. The major symptoms of this condition are walking difficulties, dyspnea caused by …

[HTML][HTML] Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells

E Shoji, H Sakurai, T Nishino, T Nakahata, T Heike… - Scientific reports, 2015 - nature.com
Duchenne muscular dystrophy (DMD) is a progressive and fatal muscle degenerating
disease caused by a dystrophin deficiency. Effective suppression of the primary pathology …