Undisclosed, unmet and neglected challenges in multi-omics studies

S Tarazona, A Arzalluz-Luque, A Conesa - Nature Computational …, 2021 - nature.com
Multi-omics approaches have become a reality in both large genomics projects and small
laboratories. However, the multi-omics research community still faces a number of issues …

[HTML][HTML] Statistical single cell multi-omics integration

M Colomé-Tatché, FJ Theis - Current Opinion in Systems Biology, 2018 - Elsevier
Single cell high throughput genomic measurements are revolutionizing the fields of biology
and medicine, providing a means to tackle biological problems that have thus far been …

[HTML][HTML] Computational strategies for single-cell multi-omics integration

N Adossa, S Khan, KT Rytkönen, LL Elo - Computational and Structural …, 2021 - Elsevier
Single-cell omics technologies are currently solving biological and medical problems that
earlier have remained elusive, such as discovery of new cell types, cellular differentiation …

[HTML][HTML] The technological landscape and applications of single-cell multi-omics

A Baysoy, Z Bai, R Satija, R Fan - Nature Reviews Molecular Cell …, 2023 - nature.com
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

[HTML][HTML] State of the field in multi-omics research: from computational needs to data mining and sharing

M Krassowski, V Das, SK Sahu, BB Misra - Frontiers in Genetics, 2020 - frontiersin.org
Multi-omics, variously called integrated omics, pan-omics, and trans-omics, aims to combine
two or more omics data sets to aid in data analysis, visualization and interpretation to …

Advances in bulk and single-cell multi-omics approaches for systems biology and precision medicine

Y Li, L Ma, D Wu, G Chen - Briefings in Bioinformatics, 2021 - academic.oup.com
Multi-omics allows the systematic understanding of the information flow across different
omics layers, while single omics can mainly reflect one aspect of the biological system. The …

Computational methods for single-cell multi-omics integration and alignment

S Stanojevic, Y Li, A Ristivojevic… - Genomics, Proteomics …, 2022 - academic.oup.com
Recently developed technologies to generate single-cell genomic data have made a
revolutionary impact in the field of biology. Multi-omics assays offer even greater …

[HTML][HTML] Advances in single-cell omics and multiomics for high-resolution molecular profiling

J Lim, C Park, M Kim, H Kim, J Kim… - Experimental & Molecular …, 2024 - nature.com
Single-cell omics technologies have revolutionized molecular profiling by providing high-
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …

[HTML][HTML] Methods and applications for single-cell and spatial multi-omics

K Vandereyken, A Sifrim, B Thienpont… - Nature Reviews Genetics, 2023 - nature.com
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …