Adipocyte-derived leptin activates multiple oncogenic signaling, leading to breast cancer
cell progression and metastasis. Hence, finding effective strategies to inhibit the oncogenic …

Obesity greatly influences risk, progression and prognosis of breast cancer. As molecular
effects of obesity are largely mediated by adipocytokine leptin, finding effective novel …

This study investigated the antiadipogenic activity of black pepper extract and its constituent
piperine in 3T3-L1 preadipocytes as well as the underlying molecular mechanisms. Both …

Simple Summary Although adipocytes affect the metastatic behavior of cancer cells, the
underlying molecular mechanisms remain largely elusive. Thereby, we sought to screen for …

Leptin, a major adipocytokine produced by adipocytes, is emerging as a key molecule
linking obesity with breast cancer therefore, it is important to find effective strategies to …

Obesity is an independent risk factor for breast cancer, and obese breast cancer patients
exhibit a higher risk for larger tumor burden and increased metastasis. Obesity, as …

Background Accumulating researches have shown that epithelial-mesenchymal transition
(EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes …

Breast cancer is one of the most common malignancies and a major cause of cancer death
among women worldwide. The high mortality rate associated with breast cancer is mainly …

Emerging evidence has suggested that leptin, an adipokine related to energy homeostasis,
plays a role in cancer growth and metastasis. However, its impact on pancreatic cancer is …

Obesity is considered as an independent risk factor for breast cancer (BCa) and plays a
major role in the breast tumor microenvironment. The etiology and mechanisms by which …