Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk
Despite the strong genetic basis of psychiatric disorders, the underlying molecular
mechanisms are largely unmapped. RNA-binding proteins (RBPs) are responsible for most …
mechanisms are largely unmapped. RNA-binding proteins (RBPs) are responsible for most …
[HTML][HTML] Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain
Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
[HTML][HTML] Genome-wide approaches to dissect the roles of RNA binding proteins in translational control: implications for neurological diseases
K Kapeli, GW Yeo - Frontiers in neuroscience, 2012 - frontiersin.org
Translational control of messenger RNAs (mRNAs) is a key aspect of neurobiology, defects
of which can lead to neurological diseases. In response to stimuli, local translation of …
of which can lead to neurological diseases. In response to stimuli, local translation of …
[HTML][HTML] Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
RNA-binding proteins in Mendelian disease
RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function
underlie a broad spectrum of human pathologies. We focus here on two recent studies that …
underlie a broad spectrum of human pathologies. We focus here on two recent studies that …
[HTML][HTML] Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders
Background Integrating rare variation from trio family and case–control studies has
successfully implicated specific genes contributing to risk of neurodevelopmental disorders …
successfully implicated specific genes contributing to risk of neurodevelopmental disorders …
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes
Mutations in gene regulatory elements have been associated with a wide range of complex
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …