Telencephalic organoids generated from human pluripotent stem cells (hPSCs) are a
promising system for studying the distinct features of the developing human brain and the …

X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female
human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon …

Background Transposable element-embedded regulatory sequences (TEeRS) and their
KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as …

The support of pluripotent cells over time is an essential feature of development. In eutherian
embryos, pluripotency is maintained from naïve states in peri-implantation to primed …

Human naive pluripotent stem cells offer a unique window into early embryogenesis studies.
Recent studies have reported several strategies to obtain cells in the naive state. However …

A hallmark of primate postimplantation embryogenesis is the specification of extraembryonic
mesoderm (EXM) before gastrulation, in contrast to rodents where this tissue is formed only …

Human naive pluripotent stem cells have unrestricted lineage potential. Underpinning this
property, naive cells are thought to lack chromatin-based lineage barriers. However, this …

As our closest living relatives, non-human primates uniquely enable explorations of human
health, disease, development, and evolution. Considerable effort has thus been devoted to …

Trophoblasts are specialized epithelial cells that perform critical functions during blastocyst
implantation and mediate maternal–fetal communication during pregnancy. However, our …

Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of
MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into …