Prior to implantation, the cells in the mammalian epiblast constitute a naïve pluripotent state,
which is distinguished by absence of lineage priming, freedom from epigenetic restriction …

Pluripotent character is described as the potency of cells to differentiate into all three germ
layers. The best example to reinstate the term lies in the context of embryonic stem cells …

The pluripotent state of embryonic stem cells (ESCs) is regulated by a sophisticated network
of transcription factors. High expression of KLF17 has recently been identified as a hallmark …

The successful reprogramming of human somatic cells into induced pluripotent stem cells
(hiPSCs) represented a turning point in the stem cell research field, owing to their ability to …

A detailed understanding of the developmental substates of human pluripotent stem cells
(hPSCs) is needed to optimize their use in cell therapy and for modeling early development …

During vertebrate development, embryonic cells pass through a continuum of transitory
pluripotent states that precede multi-lineage commitment and morphogenesis. Such states …

The placenta is a transient organ that mediates the exchange of nutrients, gases, and waste
products between the mother and the developing fetus and is indispensable for a healthy …

Obtaining functional human cells through interspecies chimerism with human pluripotent
stem cells (hPSCs) remains unsuccessful due to its extremely low efficiency. Here, we show …

A problem in developmental toxicology is the massive loss of life from fertilization through
gastrulation, and the surprising lack of knowledge of causes of miscarriage. Half to two …

Objectives Human pluripotent stem cells (hPSCs) are of great importance in both scientific
research and regenerative medicine. The most classic and widely used culture method for …