Until recently, naïve pluripotent stem cell lines were not captured from human embryos
because protocols were based upon those devised for murine embryonic stem cells. In …

Naïve pluripotent stem cells are the in vitro counterparts of pre-implantation embryonic
epiblast. During the last few years, several protocols for establishing and maintaining human …

Cardiomyocytes differentiated from human induced pluripotent stem cells (iPSCs) are
valuable for the understanding/treatment of the deadly heart diseases and their drug …

Cells of the trophoblast lineage constitute the major part of placental tissues in higher
mammals. Recent derivation of human trophoblast stem cells (TSC) from placental …

Human pluripotent stem cells exist in naïve and primed states that recapitulate the distinct
molecular and cellular properties of pre-and post-implantation epiblast cells, respectively …

Human pluripotent stem cells (hPSCs) exist in at least two distinct states in mammals: naïve
pluripotency that represents several molecular characteristics in pre-implantation epiblast …

Background Genomic imprinting (GI) is a mammalian‐specific epigenetic phenomenon that
has been implicated in the evolution of the placenta in mammals. Methods Embryo transfer …

DNA methylation represents one of the best characterized epigenetic modifications. In
particular, global demethylation is a common feature of epigenetic reprogramming to naïve …

Pluripotent cells have been stabilized from pre-and post-implantation blastocysts,
representing respectively naïve and primed stages of embryonic stem cells (ESCs) with …

The peri-implantation period from blastula to gastrula is one of the crucial stages of human
embryo and stem cell development. During development, human embryos undergo many …