Pluripotent stem cells, including induced pluripotent stem cells (iPSCs), have provided a
much-needed resource to model and improve our understanding of early human germ cell …

Naïve and primed pluripotent stem cells resemble epiblast cells of the pre-implantation and
post-implantation embryo, respectively. This chapter describes a simple experimental …

Naïve human pluripotent stem cells (hPSCs) are defined as the in vitro counterpart of the
human preimplantation embryo's epiblast and are used as a model system to study …

Progress in human pluripotent stem cells has opened up an opportunity to autologous β-cell
replacement therapies in patients with diabetes. Such an approach could render …

多能性幹細胞(pluripotent stem cells, PSCs) 具有無限自我更新(self-renewal)
與分化(differentiation) 為特定細胞的能力, 可應用於基礎及再生醫學研究 …

Background: The African spiny mouse (Acomys) is an emerging mammalian model for scar-
free regeneration, and further study of Acomys could advance the field of regenerative …

Generating patient-specific stem cells representing the onset of development has become
possible since the discovery of somatic cell reprogramming into induced pluripotent stem …

Despite pluripotent stem cells sharing key transcription factors, their maintenance involves
distinct genetic inputs. Emerging evidence suggests that super-enhancers (SEs) can …

In human embryos, naive pluripotent cells of the inner cell mass generate epiblast, primitive
endoderm and Trophectoderm (TE) lineage, whence trophoblast cells derive. In vitro, naive …

Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) are both pluripotent
stem cells from early embryos. Another type of pluripotent s tem c ells, which are similar with …