Functional diversification of oyster big defensins generates antimicrobial specificity and synergy against members of the microbiota
Big defensins are two-domain antimicrobial peptides (AMPs) that have highly diversified in
mollusks. Cg-BigDefs are expressed by immune cells in the oyster Crassostrea gigas, and …
mollusks. Cg-BigDefs are expressed by immune cells in the oyster Crassostrea gigas, and …
Pharmacokinetics and Pharmacodynamics of Fungal Defensin NZX Against Staphylococcus aureus-Induced Mouse Peritonitis Model
X Zheng, N Yang, R Mao, Y Hao, D Teng… - Frontiers in …, 2022 - frontiersin.org
Staphylococcus aureus (S. aureus) is one of the most common pathogenic bacteria
responsible for causing a life-threatening peritonitis disease. NZX, as a variant of fungal …
responsible for causing a life-threatening peritonitis disease. NZX, as a variant of fungal …
Identification of a Novel Antimicrobial Peptide From the Ancient Marine Arthropod Chinese Horseshoe Crab, Tachypleus tridentatus
WF Wang, XY Xie, Y Huang, YK Li, H Liu… - Frontiers in …, 2022 - frontiersin.org
Humoral immunity is the first line of defense in the invertebrate immune system, and
antimicrobial peptides play an important role in this biological process. A novel antimicrobial …
antimicrobial peptides play an important role in this biological process. A novel antimicrobial …
Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption
Y Sato, Y Wang, Y Song, W Geng, S Yan, K Nakamura… - Amino Acids, 2022 - Springer
Defensin is a cysteine-rich antimicrobial peptide with three disulphide bonds under normal
oxidative conditions. Cryptdin-4 (Crp4) is a defensin secreted by Paneth cells in the small …
oxidative conditions. Cryptdin-4 (Crp4) is a defensin secreted by Paneth cells in the small …
Caging pyrophosphate structure blocks the cell wall synthesis to kill bacteria without detectable resistance
The increasing spread of antimicrobial resistance results in untreatable infections, causing
thousands of deaths. Thus, it is urgent to find new antibiotics that kill the causative pathogen …
thousands of deaths. Thus, it is urgent to find new antibiotics that kill the causative pathogen …
PaP1, a broad-spectrum lysin-derived cationic peptide to treat polymicrobial skin infections
RD Heselpoth, CW Euler, VA Fischetti - Frontiers in Microbiology, 2022 - frontiersin.org
Most skin infections, including those complicating burns, are polymicrobial involving multiple
causative bacteria. Add to this the fact that many of these organisms may be antibiotic …
causative bacteria. Add to this the fact that many of these organisms may be antibiotic …
A fungal defensin inhibiting bacterial cell-wall biosynthesis with non-hemolysis and serum stability
S Qi, B Gao, S Zhu - Journal of Fungi, 2022 - mdpi.com
Defensins are a class of cationic disulfide-bridged antimicrobial peptides (AMPs) present in
many eukaryotic organisms and even in bacteria. They primarily include two distinct but …
many eukaryotic organisms and even in bacteria. They primarily include two distinct but …
Conjugation of antimicrobial peptide to zinc phthalocyanine for an efficient photodynamic antimicrobial chemotherapy
Photodynamic antimicrobial chemotherapy is an attractive and novel therapeutic approach
to treat microbial infections. Antimicrobial peptides (AMPs) have the potential to specifically …
to treat microbial infections. Antimicrobial peptides (AMPs) have the potential to specifically …
Boosting expression level of plectasin in recombinant Pichia pastoris via 2A self-processing peptide assembly
X Liang, H Jiang, X Si, Q Xin, D Meng, P Chen… - Applied Microbiology …, 2022 - Springer
Plectasin is a promising and potent antimicrobial peptide isolated from the fungus
Pseudoplectania nigrella which has been heterologously expressed in various hosts. In this …
Pseudoplectania nigrella which has been heterologously expressed in various hosts. In this …