Impact of androgen receptor activity on prostate-specific membrane antigen expression in prostate cancer cells

U Sommer, T Siciliano, C Ebersbach… - International Journal of …, 2022 - mdpi.com
Prostate-specific membrane antigen (PSMA) is an essential molecular regulator of prostate
cancer (PCa) progression coded by the FOLH1 gene. The PSMA protein has become an …

Recent advances in medical therapy for urological cancers

T Yuasa, T Urasaki, R Oki - Frontiers in Oncology, 2022 - frontiersin.org
The mainstay of medical treatment has been tyrosine kinase inhibitors (TKIs) for renal cell
cancer (RCC), cytotoxic chemotherapy for urothelial cancer (UC), and androgen deprivation …

Study protocol and preliminary results from a mono-centric cohort within a trial testing stereotactic body radiotherapy and abiraterone (ARTO-NCT03449719)

G Francolini, B Detti, V Di Cataldo, P Garlatti… - La radiologia …, 2022 - Springer
Background ARTO trial was designed to evaluate the difference in terms of outcomes
between patients affected by oligo metastatic castrate resistant prostate cancer (mCRPC) …

Where do we stand in the management of oligometastatic prostate cancer? A comprehensive review

GR Juan, FH Laura, PV Javier, VC Natalia… - Cancers, 2022 - mdpi.com
Simple Summary Oligometastatic prostate cancer is an intermediate stage between
localised and metastatic disease. Today, there are many advances in the diagnosis of this …

Survival modelling and cost-effectiveness analysis of treatments for newly diagnosed metastatic hormone-sensitive prostate cancer

MC Barbier, Y Tomonaga, D Menges, HG Yebyo… - Plos one, 2022 - journals.plos.org
Background In metastatic hormone-sensitive prostate cancer (mHSPC) treatment, survival
benefits have been shown by adding docetaxel or recent androgen receptor axis-targeted …

Rational second-generation antiandrogen use in prostate cancer

JJ Orme, LC Pagliaro, JF Quevedo, SS Park… - The …, 2022 - academic.oup.com
The second-generation antiandrogens have achieved an ever-growing list of approvals and
indications in subsets of prostate cancer. Here, we provide an overview of second …

A novel artificial intelligence–powered method for prediction of early recurrence of prostate cancer after prostatectomy and cancer drivers

W Huang, R Randhawa, P Jain, S Hubbard… - JCO Clinical Cancer …, 2022 - ascopubs.org
PURPOSE To develop a novel artificial intelligence (AI)–powered method for the prediction
of prostate cancer (PCa) early recurrence and identification of driver regions in PCa of all …

Spine stereotactic body radiotherapy for prostate cancer metastases and the impact of hormone sensitivity status on local control

A Abugharib, KL Zeng, CL Tseng, H Soliman… - …, 2022 - journals.lww.com
BACKGROUND: Stereotactic body radiotherapy (SBRT) is used to deliver ablative dose of
radiation to spinal metastases. OBJECTIVE: To report the first dedicated series of spine …

Prostate cancer treatment: 177Lu-PSMA-617 considerations, concepts, and limitations

O Sartor, K Herrmann - Journal of Nuclear Medicine, 2022 - Soc Nuclear Med
The phase III VISION trial using 177Lu-PSMA-617 has significant implications for the field of
theranostics and broad repercussions for the clinical management of prostate cancer …

A phase 1b adaptive androgen deprivation therapy trial in metastatic castration sensitive prostate cancer

J Zhang, J Gallaher, JJ Cunningham, JW Choi… - Cancers, 2022 - mdpi.com
Simple Summary Despite early utilization of new hormonal agents (NHA, ie, abiraterone,
enzalutamide and apalutamide) for combined androgen deprivation therapy (ADT) for …