[HTML][HTML] Variants of SARS CoV-2: mutations, transmissibility, virulence, drug resistance, and antibody/vaccine sensitivity

BM Prüβ - Frontiers in Bioscience-Landmark, 2022 - imrpress.com
Severe acute respiratory syndrom coronavirus-2 (SARS CoV-2) is the causative agent of
coronavirus disease-19 (Covid-19) which has been designated a worldwide pandemic by …

Molecular variants of SARS-CoV-2: antigenic properties and current vaccine efficacy

A Rayati Damavandi, R Dowran, S Al Sharif… - Medical Microbiology …, 2022 - Springer
An ongoing pandemic of newly emerged SARS-CoV-2 has puzzled many scientists and
health care policymakers around the globe. The appearance of the virus was accompanied …

[HTML][HTML] State-of-art high-performance Nano-systems for mutated coronavirus infection management: From Lab to Clinic

R Bhattacharjee, AK Dubey, A Ganguly… - OpenNano, 2022 - Elsevier
The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
made emerging novel coronavirus diseases (COVID-19) pandemic/endemic/or both more …

Computer simulations and network-based profiling of binding and allosteric interactions of SARS-CoV-2 spike variant complexes and the host receptor: dissecting the …

G Verkhivker, S Agajanian, R Kassab… - International journal of …, 2022 - mdpi.com
In this study, we combine all-atom MD simulations and comprehensive mutational scanning
of S-RBD complexes with the angiotensin-converting enzyme 2 (ACE2) host receptor in the …

Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B. 1.524 and AU. 2 in Malaysia

UA Zainulabid, AS Mat Yassim, M Hussain, A Aslam… - PLoS …, 2022 - journals.plos.org
SARS-CoV-2 has spread throughout the world since its discovery in China, and Malaysia is
no exception. WGS has been a crucial approach in studying the evolution and genetic …

[HTML][HTML] A systematic review of current status and challenges of vaccinating children against SARS-CoV-2

M Zhang, P Zhang, Y Liang, B Du, L Li, Z Yu… - Journal of Infection and …, 2022 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has inflicted immense damage to countries …

Frustration-driven allosteric regulation and signal transmission in the SARS-CoV-2 spike omicron trimer structures: A crosstalk of the omicron mutation sites …

GM Verkhivker, S Agajanian, R Kassab… - Physical Chemistry …, 2022 - pubs.rsc.org
Dissecting the regulatory principles underlying function and activity of the SARS-CoV-2
spike protein at the atomic level is of paramount importance for understanding the …

Structural and computational studies of the SARS-CoV-2 spike protein binding mechanisms with nanobodies: from structure and dynamics to avidity-driven nanobody …

G Verkhivker - International Journal of Molecular Sciences, 2022 - mdpi.com
Nanobodies provide important advantages over traditional antibodies, including their
smaller size and robust biochemical properties such as high thermal stability, high solubility …

Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike

K Qu, Q Chen, KA Ciazynska, B Liu, X Zhang… - PLoS …, 2022 - journals.plos.org
The spike (S) protein of SARS-CoV-2 has been observed in three distinct pre-fusion
conformations: locked, closed and open. Of these, the function of the locked conformation …

The Role of Lebanon in the COVID-19 Butterfly Effect: The B. 1.398 Example

D Nour, R Rafei, AP Lamarca, LGP de Almeida… - Viruses, 2022 - mdpi.com
In the present study, we provide a retrospective genomic surveillance of the SARS-CoV-2
pandemic in Lebanon; we newly sequence the viral genomes of 200 nasopharyngeal …