Objectives The primary objective of this study was to investigate the efficacy of cold therapy
in reducing paclitaxel-based, chemotherapy-induced, peripheral neuropathy (CIPN). The …

The distinction between glial painful and protective pathways is unclear and the possibility to
finely modulate the system is lacking. Focusing on painful neuropathies, we studied the role …

Background: Pain and numbness in cancer survivors frequently have negative impacts on
quality of life (QoL). This meta-analysis aimed to identify the current treatment options for …

Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of
several cancer chemotherapeutic agents, and no effective therapies exist. Here we …

Chemotherapy-induced neuropathic pain is a common side effect for cancer patients which
has limited effective treatment options. Kappa opioid receptor (KOR) agonists are a …

Taxane-induced peripheral neuropathy (TIPN) is a devastating survivorship issue for many
cancer patients. In addition to its impact on quality of life, this toxicity may lead to dose …

Neurotoxicity of chemotherapeutics involves peculiar alterations in the structure and
function, including abnormal nerve signal transmission, of both the peripheral and central …

Simple Summary Chemotherapy-induced peripheral neuropathy (CIPN) is a common
complication due to treatment with anti-cancer agents. Our aim was therefore to assess the …

Duloxetine, a serotonin and norepinephrine reuptake inhibitor, is the best-established
treatment for painful chemotherapy-induced peripheral neuropathy (CIPN). While it is only …

The purpose of this integrative review of the literature is to synthesize the current evidence
and identify gaps in knowledge regarding the effectiveness of acupuncture to treat …