Long-term safety and efficacy of anacetrapib in patients with atherosclerotic vascular disease

HPS3/TIMI55-REVEAL Collaborative … - European Heart …, 2022 - academic.oup.com
Aims REVEAL was the first randomized controlled trial to demonstrate that adding
cholesteryl ester transfer protein inhibitor therapy to intensive statin therapy reduced the risk …

[HTML][HTML] Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Y Hu, X Chen, M Hu, D Zhang, S Yuan, P Li, L Feng - Chinese Medicine, 2022 - Springer
Dyslipidemia is an independent risk factor of cardiovascular diseases (CVDs), which lead to
the high mortality, disability, and medical expenses in the worldwide. Based on the previous …

[HTML][HTML] Statins and cognition: Modifying factors and possible underlying mechanisms

T Jamshidnejad-Tosaramandani… - Frontiers in Aging …, 2022 - frontiersin.org
Statins are a class of widely prescribed drugs used to reduce low-density lipoprotein
cholesterol (LDL-C) and important to prevent cardiovascular diseases (CVD). Most statin …

Statin associated muscle symptoms: An update and review

W Dicken, A Mehta, A Karagiannis, V Jain… - Progress in …, 2022 - Elsevier
Statin therapy has been shown to have a significant effect on lowering of low-density
lipoprotien cholesterol (LDL-C) levels. This subsequently results in cardiovascular (CV) …

[HTML][HTML] Statins and prostate cancer—hype or hope? The epidemiological perspective

EL Craig, KH Stopsack, E Evergren, LZ Penn… - Prostate cancer and …, 2022 - nature.com
Background Men using cholesterol-lowering statin medications have been found to have
lower risks of both advanced and fatal prostate cancer in multiple registry-based studies and …

Integrating a polygenic risk score for coronary artery disease as a risk‐enhancing factor in the pooled cohort equation: a cost‐effectiveness analysis study

D Mujwara, G Henno, ST Vernon, S Peng… - Journal of the …, 2022 - Am Heart Assoc
Background Cardiovascular diseases are the leading cause of death in the United States,
yet a significant proportion of adults at high risk remain undetected by standard screening …

Intensity of and adherence to lipid‐lowering therapy as predictors of major adverse cardiovascular outcomes in patients with coronary heart disease

F Mazhar, P Hjemdahl, CM Clase… - Journal of the …, 2022 - Am Heart Assoc
Background The effectiveness of lipid‐lowering therapy (LLT) is affected by both intensity
and adherence. This study evaluated the associations of LLT intensity, adherence, and the …

Inflammation in coronary atherosclerosis and its therapeutic implications

NJ Montarello, MT Nguyen, DTL Wong… - … drugs and therapy, 2022 - Springer
Atherosclerotic coronary artery disease has a complex pathogenesis which extends beyond
cholesterol intimal infiltration. It involves chronic inflammation of the coronary artery wall …

The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on …

EF Magavern, JC Kaski, RM Turner… - European Heart …, 2022 - academic.oup.com
There is a strong and ever-growing body of evidence regarding the use of
pharmacogenomics to inform cardiovascular pharmacology. However, there is no common …

Net benefit, calibration, threshold selection, and training objectives for algorithmic fairness in healthcare

S Pfohl, Y Xu, A Foryciarz, N Ignatiadis… - Proceedings of the …, 2022 - dl.acm.org
A growing body of work uses the paradigm of algorithmic fairness to frame the development
of techniques to anticipate and proactively mitigate the introduction or exacerbation of health …