Epidemic obesity is the most important risk factor for prediabetes and type 2 diabetes (T2D)
in youth as it is in adults. Obesity shares pathophysiological mechanisms with T2D and is …

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via mRNA
targeting, playing important roles in the pancreatic islets. We aimed to identify molecular …

Background Genome-wide association studies (GWASs) have identified multiple risk loci for
bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported …

The incidence of type 2 diabetes (T2D) is on the rise in youth in the US 1, 2 and worldwide. 3
T2D is characterized by hyperglycemia from a combination of insulin resistance and relative …

There is growing evidence that sex and gender differences play an important role in risk and
pathophysiology of type 2 diabetes (T2D). Men develop T2D earlier than women, even …

Gout is a chronic disease of monosodium urate crystal deposition in the setting of
hyperuricemia that typically presents with recurrent flares of acute inflammatory arthritis that …

Voltage‐gated potassium (Kv) channels play an important role in the repolarization of a
variety of excitable tissues, including in the cardiomyocyte and the pancreatic beta cell …

Preproinsulin (PPI) translocation across the membrane of the endoplasmic reticulum (ER) is
the first and critical step of insulin biosynthesis. Inefficient PPI translocation caused by signal …

Prevalence of obesity, type 2 diabetes (T2D), and being born with low birth weight are much
higher in African American women compared to US white women. Genetic factors may …

Aims/hypothesis Imbalances in glucose metabolism are hallmarks of clinically silent
prediabetes (defined as impaired fasting glucose and/or impaired glucose tolerance) …