Hypothermia is defined as a core body temperature of< 35° C, and as body temperature is
reduced the impact on physiological processes can be beneficial or detrimental. The …

Introduction The global health burden of stroke is significant and few therapeutic treatment
options currently exist for patients. Pre-clinical research relies heavily on rodent stroke …

Extracellular vesicles (EVs) are lipid bilayer-enclosed structures that represent newly
discovered means for cell-to-cell communication as well as promising disease biomarkers …

Glutamate excitotoxicity due to its accumulation in the extracellular space is a major factor to
the brain damage that occurs during the early stages of cerebral ischemia 1. GLT-1 is mainly …

Cerebral ischemia is an acute disorder characterized by an abrupt reduction in blood flow
that results in immediate deprivation of both glucose and oxygen. The main types of cerebral …

Background and purpose Fine particulate matter (PM 2.5) has been associated with
increased risks of stroke, but it remains unclear which specific size ranges and chemical …

The local microenvironment is essential to stem cell-based therapy for ischemic stroke, and
spatiotemporal changes of the microenvironment in the pathological process provide vital …

In this review, we provide recent data on the role of mTOR kinase in the brain under
physiological conditions and after damage, with a particular focus on cerebral ischemia. We …

Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in
physiological and different pathophysiological conditions. Ischemic stroke has a complex …

Understanding the mechanisms underlying ischemic brain injury is import to the goal of
devising novel therapeutics for protection and/or recovery. Previous work in our laboratory …